1rvf: Difference between revisions
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvf OCA], [http://www.ebi.ac.uk/pdbsum/1rvf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rvf RCSB]</span> | |||
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==About this Structure== | ==About this Structure== | ||
1RVF is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ | 1RVF is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_rhinovirus_14 Human rhinovirus 14], [http://en.wikipedia.org/wiki/Human_rhinovirus_sp. Human rhinovirus sp.] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The following page contains interesting information on the relation of 1RVF with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb20_1.html Poliovirus and Rhinovirus]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVF OCA]. | ||
==Reference== | ==Reference== | ||
Neutralizing antibody to human rhinovirus 14 penetrates the receptor-binding canyon., Smith TJ, Chase ES, Schmidt TJ, Olson NH, Baker TS, Nature. 1996 Sep 26;383(6598):350-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8848050 8848050] | Neutralizing antibody to human rhinovirus 14 penetrates the receptor-binding canyon., Smith TJ, Chase ES, Schmidt TJ, Olson NH, Baker TS, Nature. 1996 Sep 26;383(6598):350-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8848050 8848050] | ||
[[Category: Human rhinovirus | [[Category: Human rhinovirus 14]] | ||
[[Category: Human rhinovirus sp.]] | [[Category: Human rhinovirus sp.]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
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[[Category: thiol protease]] | [[Category: thiol protease]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:33:31 2008'' | ||
Revision as of 23:33, 30 March 2008
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| , resolution 4.0Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
FAB COMPLEXED WITH INTACT HUMAN RHINOVIRUS
OverviewOverview
The three-dimensional structure of intact human rhinovirus 14 (HRV-14) complexed with Fab fragments (Fab17-IA) from a strongly neutralizing antibody that binds bivalently to the virion has been determined to 4.0 angstrom resolution by a combination of X-ray crystallography and cryo-electron microscopy. In contradiction to the most commonly held model of antibody-mediated neutralization, Fab17-IA does not induce a conformational change in the HRV-14 capsid. Instead, the paratope of the antibody undergoes a large conformational change to accommodate the epitope. Unlike any previously described antibody-antigen structure, the conserved framework region of the antibody makes extensive contact with the viral surface. Fab17-IA penetrates deep within the canyon in which the cellular receptor for HRV-14 binds. Hence, it is unlikely that viral quaternary structure evolves merely to evade immune recognition. Instead, the shape and position of the receptor-binding region on a virus probably dictates receptor binding and subsequent uncoating events and has little or no influence on concealing the virus from the immune system.
About this StructureAbout this Structure
1RVF is a Protein complex structure of sequences from Human rhinovirus 14, Human rhinovirus sp. and Mus musculus. The following page contains interesting information on the relation of 1RVF with [Poliovirus and Rhinovirus]. Full crystallographic information is available from OCA.
ReferenceReference
Neutralizing antibody to human rhinovirus 14 penetrates the receptor-binding canyon., Smith TJ, Chase ES, Schmidt TJ, Olson NH, Baker TS, Nature. 1996 Sep 26;383(6598):350-4. PMID:8848050
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