Rho GTPase activating protein: Difference between revisions

Revision as of 11:46, 23 January 2017

Function

Rho GTPase activating protein (RhoGAP) are one of the main classes of Rho GTPase regulators that are crucial in cell cytoskeletal organization, growth, differentiation, neuronal development and synaptic functions^[1]. RhoGAPs contain a RhoGAP domain.

Relevance

RhoGAPs are present in altered abundance in a variety of human cancers and may serve as targets for cancer therapy^[2].

Structural highlights

The active site of RhoGAP contains a catalytic arginine and GDP^[3].

Human RhoGAP 1 (grey) complex with RhoA (green), GDP, MgF3 and Mg+2 ions (PDB code 1ow3)

Drag the structure with the mouse to rotate

3D structures of Rho GTPase activating protein3D structures of Rho GTPase activating protein

Updated on 23-January-2017

4u3k - yRhoGAP 1 RhoGAP domain - yeast
1ow3 - hRhoGAP 1 residues 198-439 + RhoA + GDP - human
5irc - RhoGAP 35 + RhoA - rat
4rtt, 4rug, 2gnc - hRhoGAP 2 SLIT-ROBO SH3 domain
2dl8 - hRhoGAP 2 SLIT-ROBO SH3 domain - NMR
2epd - hRhoGAP 4 SH3 domain - NMR
2ee4 , 2ee5 - hRhoGAP 5 (mutant) RhoGAP domain - NMR
3kuq - hRhoGAP 7 RhoGAP domain
2kap, 2dky - hRhoGAP 7 SAM domain - NMR
2p0d, 2p0f, 2p0h - hRhoGAP 9 pleckstrin homology domain + phosphoinositide
2mio - hRhoGAP 10 SH3 domain - NMR
2j59 - hRhoGAP 10 ARF-binding domain + ADP-ribosylation factor
3eap - hRhoGAP 11A RhoGAP domain
3byi - RhoGAP 15 residues 262-473
3msx - hRhoGAP 20 RhoGAP domain + RhoA
2yuy - hRhoGAP 21 PDZ domain - NMR
2dhj - hRhoGAP 21 pleckstrin homology domain - NMR
3pp2 - hRhoGAP 27 pleckstrin homology domain
4wpc - yRhoGAP 1 F-BARR domain + inositol phosphate
1grn - hRhoGAP C-terminal + GTP-binding protein

ReferencesReferences

↑ Moon SY, Zheng Y. Rho GTPase-activating proteins in cell regulation. Trends Cell Biol. 2003 Jan;13(1):13-22. PMID:12480336
↑ Kandpal RP. Rho GTPase activating proteins in cancer phenotypes. Curr Protein Pept Sci. 2006 Aug;7(4):355-65. PMID:16918449
↑ Graham DL, Lowe PN, Grime GW, Marsh M, Rittinger K, Smerdon SJ, Gamblin SJ, Eccleston JF. MgF(3)(-) as a transition state analog of phosphoryl transfer. Chem Biol. 2002 Mar;9(3):375-81. PMID:11927263

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

[1] Moon SY, Zheng Y. Rho GTPase-activating proteins in cell regulation. Trends Cell Biol. 2003 Jan;13(1):13-22. PMID:12480336

[2] Kandpal RP. Rho GTPase activating proteins in cancer phenotypes. Curr Protein Pept Sci. 2006 Aug;7(4):355-65. PMID:16918449

[3] Graham DL, Lowe PN, Grime GW, Marsh M, Rittinger K, Smerdon SJ, Gamblin SJ, Eccleston JF. MgF(3)(-) as a transition state analog of phosphoryl transfer. Chem Biol. 2002 Mar;9(3):375-81. PMID:11927263

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@@ Line 2: / Line 2: @@
 == Function ==
-'''Rho GTPase acivating protein''' (RhoGAP) are one of the main classes of Rho GTPase regulators that are crucial in cell cytoskeletal organization, growth, differentiation, neuronal development and synaptic functions<ref>PMID:12480336</ref>.  RhoGAPs contain a RhoGAP domain.
+'''Rho GTPase activating protein''' (RhoGAP) are one of the main classes of Rho GTPase regulators that are crucial in cell cytoskeletal organization, growth, differentiation, neuronal development and synaptic functions<ref>PMID:12480336</ref>.  RhoGAPs contain a RhoGAP domain.
 == Relevance ==