P53: Difference between revisions
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[[Image:P53_surface_charge.png | left | 250 px | thumb]]The figure at the left shows the surface charge of the p53 DNA-binding domain )Charged: red - negative; blue - positive). It is rich in arginine amino acids that interact with DNA, and this causes its surface to be positively charged. This domain recognizes specific regulatory sites on the DNA. The flexible structure of p53 allows it to bind to many different variants of binding sites, allowing it to regulate transcription at many places in the genome. | [[Image:P53_surface_charge.png | left | 250 px | thumb]]The figure at the left shows the surface charge of the p53 DNA-binding domain )Charged: red - negative; blue - positive). It is rich in arginine amino acids that interact with DNA, and this causes its surface to be positively charged. This domain recognizes specific regulatory sites on the DNA. The flexible structure of p53 allows it to bind to many different variants of binding sites, allowing it to regulate transcription at many places in the genome. | ||
There is a Zn-binding motif on p53. The p53 Zn atom is coordinated by residues | There is a Zn-binding motif on p53. The p53 Zn atom is coordinated by residues | ||