P53: Difference between revisions
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<StructureSection load='1tup' size='350' side='right' scene='26/26327/Initl/2' caption='Human p53 DNA-binding domain complex with DNA and Zn+2 ions (grey) (PDB code [[1tup]])'> | <StructureSection load='1tup' size='350' side='right' scene='26/26327/Initl/2' caption='Human p53 DNA-binding domain complex with DNA and Zn+2 ions (grey) (PDB code [[1tup]])'> | ||
[[Image:P53_DNA.png|left|150px]]<br /> | [[Image:P53_DNA.png|left|150px]]<br /> | ||
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=='''p53 Tumor Suppressor Protein (PDB code [[1tup]])'''== | =='''p53 Tumor Suppressor Protein (PDB code [[1tup]])'''== | ||
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The figure at the left shows the surface charge of the p53 DNA-binding domain. It is rich in arginine amino acids that interact with DNA, and this causes its surface to be positively charged. This domain recognizes specific regulatory sites on the DNA. The flexible structure of p53 allows it to bind to many different variants of binding sites, allowing it to regulate transcription at many places in the genome. | The figure at the left shows the surface charge of the p53 DNA-binding domain. It is rich in arginine amino acids that interact with DNA, and this causes its surface to be positively charged. This domain recognizes specific regulatory sites on the DNA. The flexible structure of p53 allows it to bind to many different variants of binding sites, allowing it to regulate transcription at many places in the genome. | ||
<scene name='Sandbox/P53_dna_binding_domain/1'>Click Here to view a Three-dimensional Representation of the DNA-binding Domain Bound to DNA</scene> | <scene name='Sandbox/P53_dna_binding_domain/1'>Click Here to view a Three-dimensional Representation of the DNA-binding Domain Bound to DNA</scene> | ||