Lipase: Difference between revisions

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David Canner, Joel L. Sussman, Eran Hodis, Alexander Berchansky, Michal Harel, Stephanie Schell, Natalie Ziegler, Quinn R. Murray, Katelyn Clark, Leben Tadesse, Eric Martz

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 == '''Introduction''' ==
-'''Lipase''' catalyzes the breakdown of lipids by hydrolyzing the esters of fatty acids.  Its function is important for digestion and promoting absorption of fats in the intestines.  Lipase is primarily found in and secreted by the pancreas, but is also found in the saliva and stomach.  Pancreatic lipase (PDB ID:  [[1hpl]]) which is pictured to the right, is a carboxylic ester hydrolase.  It is also commonly called pancreatic triacylglycerol lipase and its enzyme class number is E.C. 3.1.1.3 <ref name="1HPL PDB SUM">[http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1hpl&template=main.html] 1HPL PDB SUM </ref>.  The bile salt-stimulated lipase (BSSL) is found in breast milk.  The hormone-sensitive lipase (LIPE) hydrolyzes a variety of esters.  Monoacylglycerol lipase (MAGL) hydrolyzes intracellular triglycerides to fatty acid and glycerol.  MAGL functions together with LIPE.  The reaction catalyzed by the enzyme is shown below.
+'''Lipase''' catalyzes the breakdown of lipids by hydrolyzing the esters of fatty acids.  Its function is important for digestion and promoting absorption of fats in the intestines.  Lipase is primarily found in and secreted by the pancreas, but is also found in the saliva and stomach.<br />
+* '''Pancreatic lipase''' (PDB ID:  [[1hpl]]) which is pictured to the right, is a carboxylic ester hydrolase.  It is also commonly called '''pancreatic triacylglycerol lipase''' and its enzyme class number is E.C. 3.1.1.3 <ref name="1HPL PDB SUM">[http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1hpl&template=main.html] 1HPL PDB SUM </ref>.<br />
+*  The '''bile salt-stimulated lipase''' (BSSL) is found in breast milk.<br />
+*  The '''hormone-sensitive lipase''' (LIPE) hydrolyzes a variety of esters.<br />
+*  '''Monoacylglycerol lipase''' (MAGL) hydrolyzes intracellular triglycerides to fatty acid and glycerol.  MAGL functions together with LIPE.  The reaction catalyzed by the enzyme is shown below.
+For more details on eukaryotic lipase see [[Human gastric lipase]].
 [[Image:Picture 1.png]]