5kyo: Difference between revisions

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-'''Unreleased structure'''
-The entry 5kyo is ON HOLD  until Paper Publication
+==Crystal Structure of CYP101J2==
+<StructureSection load='5kyo' size='340' side='right' caption='[[5kyo]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5kyo]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KYO FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kyo OCA], [http://pdbe.org/5kyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kyo RCSB], [http://www.ebi.ac.uk/pdbsum/5kyo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kyo ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The cytochrome P450 monooxygenases (P450s) catalyse a vast array of oxygenation reactions that can be useful in biocatalytic applications. CYP101J2 from Sphingobium yanoikuyae is a P450 that catalyses the hydroxylation of 1,8-cineole. Here we report the crystallisation and X-ray structure elucidation of recombinant CYP101J2 to 1.8 A resolution. The CYP101J2 structure shows the canonical P450-fold and has an open conformation in the absence of substrate. Analysis of the structure revealed that CYP101J2, in the absence of substrate, forms a well-ordered substrate-binding channel that suggests a unique form of substrate guidance in comparison to other bacterial 1,8-cineole-hydroxylating P450 enzymes. This article is protected by copyright. All rights reserved.
-Authors: Unterweger, B., Drinkwater, N., Dumsday, G.J., McGowan, S.
+X-ray crystal structure of cytochrome P450 monooxygenase CYP101J2 from Sphingobium yanoikuyae strain B2.,Unterweger B, Drinkwater N, Johanesen P, Lyras D, Dumsday GJ, McGowan S Proteins. 2016 Dec 9. doi: 10.1002/prot.25227. PMID:27936485<ref>PMID:27936485</ref>
-Description: Crystal Structure of CYP101J2
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Dumsday, G.J]]
+<div class="pdbe-citations 5kyo" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Drinkwater, N]]
+[[Category: Dumsday, G J]]
+[[Category: McGowan, S]]
 [[Category: Unterweger, B]]
-[[Category: Mcgowan, S]]
+[[Category: 8-cineole hydroxylation]]
+[[Category: Cytochrome p450 monooxygenase]]
+[[Category: Oxidoreductase]]