5fg8: Difference between revisions

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'''Unreleased structure'''


The entry 5fg8 is ON HOLD until Paper Publication
==Drosophila CaMKII-wt in complex with a fragment of the Eag potassium channel and Mg2+/ADP==
 
<StructureSection load='5fg8' size='340' side='right' caption='[[5fg8]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5fg8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FG8 FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fg8 OCA], [http://pdbe.org/5fg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fg8 RCSB], [http://www.ebi.ac.uk/pdbsum/5fg8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fg8 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/KCC2A_DROME KCC2A_DROME]] A key regulator of plasticity in synaptic physiology and behavior, alterations in its activity produce pleiotrophic effects that involve synaptic transmission and development as well as various aspects of behavior. Directly modulates eag potassium channels.<ref>PMID:11980904</ref> <ref>PMID:14687552</ref>  [[http://www.uniprot.org/uniprot/KCNAE_DROME KCNAE_DROME]] Structural component of a potassium channel. Mediates the potassium permeability of membranes; potassium current is regulated by CaMKII and CASK. Has a role in growth of the perineurial glial layer of the larval peripheral nerve.<ref>PMID:11517334</ref> <ref>PMID:11980904</ref> <ref>PMID:15901771</ref> <ref>PMID:1840699</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Calcium/calmodulin-dependent protein kinase]]
[[Category: Castro-Rodrigues, A F]]
[[Category: Morais-Cabral, J H]]
[[Category: Complex]]
[[Category: Potassium channel]]
[[Category: Protein kinase]]
[[Category: Transferase]]

Revision as of 19:21, 2 January 2017

Drosophila CaMKII-wt in complex with a fragment of the Eag potassium channel and Mg2+/ADPDrosophila CaMKII-wt in complex with a fragment of the Eag potassium channel and Mg2+/ADP

Structural highlights

5fg8 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Activity:Calcium/calmodulin-dependent protein kinase, with EC number 2.7.11.17
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[KCC2A_DROME] A key regulator of plasticity in synaptic physiology and behavior, alterations in its activity produce pleiotrophic effects that involve synaptic transmission and development as well as various aspects of behavior. Directly modulates eag potassium channels.[1] [2] [KCNAE_DROME] Structural component of a potassium channel. Mediates the potassium permeability of membranes; potassium current is regulated by CaMKII and CASK. Has a role in growth of the perineurial glial layer of the larval peripheral nerve.[3] [4] [5] [6]

References

  1. ↑ Wang Z, Wilson GF, Griffith LC. Calcium/calmodulin-dependent protein kinase II phosphorylates and regulates the Drosophila eag potassium channel. J Biol Chem. 2002 Jul 5;277(27):24022-9. Epub 2002 Apr 29. PMID:11980904 doi:http://dx.doi.org/10.1074/jbc.M201949200
  2. ↑ Lu CS, Hodge JJ, Mehren J, Sun XX, Griffith LC. Regulation of the Ca2+/CaM-responsive pool of CaMKII by scaffold-dependent autophosphorylation. Neuron. 2003 Dec 18;40(6):1185-97. PMID:14687552
  3. ↑ Yager J, Richards S, Hekmat-Scafe DS, Hurd DD, Sundaresan V, Caprette DR, Saxton WM, Carlson JR, Stern M. Control of Drosophila perineurial glial growth by interacting neurotransmitter-mediated signaling pathways. Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10445-50. Epub 2001 Aug 21. PMID:11517334 doi:http://dx.doi.org/10.1073/pnas.191107698
  4. ↑ Wang Z, Wilson GF, Griffith LC. Calcium/calmodulin-dependent protein kinase II phosphorylates and regulates the Drosophila eag potassium channel. J Biol Chem. 2002 Jul 5;277(27):24022-9. Epub 2002 Apr 29. PMID:11980904 doi:http://dx.doi.org/10.1074/jbc.M201949200
  5. ↑ Marble DD, Hegle AP, Snyder ED 2nd, Dimitratos S, Bryant PJ, Wilson GF. Camguk/CASK enhances Ether-a-go-go potassium current by a phosphorylation-dependent mechanism. J Neurosci. 2005 May 18;25(20):4898-907. PMID:15901771 doi:http://dx.doi.org/10.1523/JNEUROSCI.4566-04.2005
  6. ↑ Warmke J, Drysdale R, Ganetzky B. A distinct potassium channel polypeptide encoded by the Drosophila eag locus. Science. 1991 Jun 14;252(5012):1560-2. PMID:1840699

5fg8, resolution 1.96Å

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