Siderocalin: Difference between revisions
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<StructureSection load='1x89' size='340' side='right' caption=' | <StructureSection load='1x89' size='340' side='right' caption='Human siderocalin complex with the siderophore carboxymycobactin (PDB code [[1x89]])' scene='' > | ||
== Function == | == Function == | ||
'''Siderocalin''' (Scn) binds ferric siderophores in order to intercept delivery of iron to bacteria which require it thus impeding their virulence<ref>PMID:19053425</ref>. | '''Siderocalin''' (Scn) binds ferric siderophores in order to intercept delivery of iron to bacteria which require it thus impeding their virulence<ref>PMID:19053425</ref>. | ||
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== Relevance == | == Relevance == | ||
Scn-NGAL levels are markedly upregulated by tissue damage. Scn-NGAL is derived from damaged kidneys. The presence of Scn-NGAL in serum or urine anticipates a severe course for the patient including the need for dialysis and the possibility of death<ref>PMID:22728330</ref>. | Scn-NGAL levels are markedly upregulated by tissue damage. Scn-NGAL is derived from damaged kidneys. The presence of Scn-NGAL in serum or urine anticipates a severe course for the patient including the need for dialysis and the possibility of death<ref>PMID:22728330</ref>. | ||
== Structural highlights == | |||
Scn-NGAL interacts with the siderophore carboxymycobactin where the latter is centered in the protein calyx making multiple interactions including cation-π bonds involving several lysines and arginine<ref>PMID:15642259</ref>. | |||
</StructureSection> | </StructureSection> | ||