5ttf: Difference between revisions

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-'''Unreleased structure'''
-The entry 5ttf is ON HOLD
+==Crystal structure of catalytic domain of G9a with MS012==
+<StructureSection load='5ttf' size='340' side='right' caption='[[5ttf]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
-Authors: DONG, A., ZENG, H., LIU, J., XIONG, Y., BABAULT, N., JIN, J., TEMPEL, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., WU, H., BROWN, P.J., Structural Genomics Consortium (SGC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ttf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TTF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TTF FirstGlance]. <br>
-Description: Crystal structure of catalytic domain of G9a with MS012
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7KZ:N4-(1-METHYLPIPERIDIN-4-YL)-N2-HEXYL-6,7-DIMETHOXYQUINAZOLINE-2,4-DIAMINE'>7KZ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ttg|5ttg]]</td></tr>
-[[Category: Dong, A]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ttf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ttf OCA], [http://pdbe.org/5ttf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ttf RCSB], [http://www.ebi.ac.uk/pdbsum/5ttf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ttf ProSAT]</span></td></tr>
-[[Category: Zeng, H]]
+</table>
-[[Category: Babault, N]]
+== Function ==
-[[Category: Liu, J]]
+[[http://www.uniprot.org/uniprot/EHMT2_HUMAN EHMT2_HUMAN]] Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.<ref>PMID:8457211</ref> <ref>PMID:11316813</ref> <ref>PMID:18438403</ref> <ref>PMID:20118233</ref> <ref>PMID:22387026</ref>
-[[Category: Wu, H]]
+== References ==
-[[Category: Jin, J]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arrowsmith, C H]]
+[[Category: BABAULT, N]]
+[[Category: BROWN, P J]]
 [[Category: Bountra, C]]
-[[Category: Tempel, W]]
+[[Category: DONG, A]]
-[[Category: Arrowsmith, C.H]]
+[[Category: Edwards, A M]]
-[[Category: Brown, P.J]]
+[[Category: JIN, J]]
-[[Category: Xiong, Y]]
+[[Category: LIU, J]]
-[[Category: Edwards, A.M]]
+[[Category: Structural genomic]]
-[[Category: Structural Genomics Consortium (Sgc)]]
+[[Category: TEMPEL, W]]
+[[Category: WU, H]]
+[[Category: XIONG, Y]]
+[[Category: ZENG, H]]
+[[Category: Bat8]]
+[[Category: Ehmt2]]
+[[Category: G9a]]
+[[Category: Methyltransferase]]
+[[Category: Sgc]]
+[[Category: Transferase]]
+[[Category: Unc3832]]