1qxo: Difference between revisions
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|PDB= 1qxo |SIZE=350|CAPTION= <scene name='initialview01'>1qxo</scene>, resolution 2.0Å | |PDB= 1qxo |SIZE=350|CAPTION= <scene name='initialview01'>1qxo</scene>, resolution 2.0Å | ||
|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPS:5-[(1-CARBOXYVINYL)OXY]-4-HYDROXY-3-(PHOSPHONOOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>EPS</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE+ION'>NCO</scene> | ||
|ACTIVITY= [http://en.wikipedia.org/wiki/Chorismate_synthase Chorismate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.5 4.2.3.5] | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Chorismate_synthase Chorismate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.5 4.2.3.5] </span> | ||
|GENE= AROC, SP1374 OR SPR1232 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae]) | |GENE= AROC, SP1374 OR SPR1232 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae]) | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qxo OCA], [http://www.ebi.ac.uk/pdbsum/1qxo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qxo RCSB]</span> | |||
}} | }} | ||
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[[Category: Ali, S.]] | [[Category: Ali, S.]] | ||
[[Category: Maclean, J.]] | [[Category: Maclean, J.]] | ||
[[Category: anti-infective]] | [[Category: anti-infective]] | ||
[[Category: beta-alpha-beta]] | [[Category: beta-alpha-beta]] | ||
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[[Category: shikimate]] | [[Category: shikimate]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:20:27 2008'' | ||
Revision as of 23:20, 30 March 2008
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| , resolution 2.0Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , | ||||||
| Gene: | AROC, SP1374 OR SPR1232 (Streptococcus pneumoniae) | ||||||
| Activity: | Chorismate synthase, with EC number 4.2.3.5 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of Chorismate synthase complexed with oxidized FMN and EPSP
OverviewOverview
The crystal structure of chorismate synthase (CS) from Streptococcus pneumoniae has been solved to 2.0 A resolution in the presence of flavin mononucleotide (FMN) and the substrate 5-enolpyruvyl-3-shikimate phosphate (EPSP). CS catalyses the final step of the shikimate pathway and is a potential therapeutic target for the rational design of novel antibacterials, antifungals, antiprotozoals, and herbicides. CS is a tetramer with the monomer possessing a novel beta-alpha-beta fold. The interactions between the enzyme, cofactor, and substrate reveal the structural reasons underlying the unique catalytic mechanism and identify the amino acids involved. This structure provides the essential initial information necessary for the generation of novel anti-infective compounds by a structure-guided medicinal chemistry approach.
About this StructureAbout this Structure
1QXO is a Single protein structure of sequence from Streptococcus pneumoniae. Full crystallographic information is available from OCA.
ReferenceReference
The structure of chorismate synthase reveals a novel flavin binding site fundamental to a unique chemical reaction., Maclean J, Ali S, Structure. 2003 Dec;11(12):1499-511. PMID:14656434
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