Folylpolyglutamate synthase: Difference between revisions

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Michal Harel, Jaime Prilusky, Alexander Berchansky, Joel L. Sussman, Karsten Theis

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-<StructureSection load='2vor' size='340' side='right' caption='Folypolyglutamate synthase complex with ADP, AMPPCP and Co+2 ion (pink) (PDB code [[2vor]]' scene=''>
+<StructureSection load='2vor' size='340' side='right' caption='Folypolyglutamate synthase complex with ADP, AMPPCP and Co+2 ion (pink) (PDB code [[2vor]])' scene=''>
 == Function ==
 '''Folypolyglutamate synthase''' (FPGS)  is active in intracellular folate homeostasis.  Polyglutamated folates are substrates for generation of the primary metyhl group donor S-adenosylmethionine (SAM)<ref>PMID:26895662</ref>.
 == Disease ==
+Mutations in FPGS are associated with increased childhood acute lymphoblastic leukemia<ref>PMID:26107232</ref>.
 == Relevance ==
 FPGS status is a predictor of chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate based chemotherapy and FPGS gene transfer may increase the sensitivity of colon cancer cells to 5-FU-based chemotherapy<ref>PMID:15542523</ref>.
 == Structural highlights ==
+The nucleotide -binding pocket of FPGS occupies a narrow channel between the N- and C-terminal domains of the protein and contains the nucleotide and a divalent ion<ref>PMID:18566510</ref>.
-This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
 </StructureSection>
 ==3D structures of folypolyglutamate synthase==