Virus coat protein: Difference between revisions
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<StructureSection load='3gv2' size='350' side='right' caption='Structure of HIV-I coat protein hexamer (PDB entry [[3gv2]])' scene=''> | <StructureSection load='3gv2' size='350' side='right' caption='Structure of HIV-I coat protein hexamer (PDB entry [[3gv2]])' scene=''> | ||
'''Virus coat proteins''' (VCP) or capsid proteins coat the virus<ref>PMID:19825049</ref>. The various VCPs are designated as Vp1, Vp2, etc. The VCP P domain (protruding domain) in noroviruses binds histo blood group antigen receptors. | '''Virus coat proteins''' (VCP) or capsid proteins coat the virus<ref>PMID:19825049</ref>. The various VCPs are designated as Vp1, Vp2, etc. The VCP P domain (protruding domain) in noroviruses binds histo blood group antigen receptors. The outer capsid protein '''VP4''' is a virus spike-forming protein which mediates the virial attachment to the host epithelial cell receptors. VP4 is an outer capsid protein of non-enveloped viruses. VP4 attaches to sialic acid or to integrin heterodimers<ref>PMID:2538649</ref>. VP4 domains include: '''VP5*''' which forms the foot of the spike and acts in the permeabilization of the cell membrane and '''VP8*''' which forms the head of the spike and binds to sialic acid. | ||
</StructureSection> | </StructureSection> | ||
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**[[1qhd]] – brvVCP Vp6 – bovine rotavirus<br /> | **[[1qhd]] – brvVCP Vp6 – bovine rotavirus<br /> | ||
**[[3kz4]] - brvVCP Vp2<br /> | **[[3kz4]] - brvVCP Vp2<br /> | ||
**[[ | **[[4v7q]] - rrVCP Vp4 – rhesus rotavirus – Cryo EM<br /> | ||
**[[2p3j]] – rrVCP Vp4 (mutant) <br /> | **[[2p3i]], [[2p3k]] - rrVCP Vp4 Vp8* domain <br /> | ||
**[[2p3j]] – rrVCP Vp4 Vp8* domain (mutant) <br /> | |||
**[[1kri]] - rrVCP Vp4 Vp8* domain – NMR<br /> | |||
**[[2b4h]], [[2b4i]], [[1slq]] - Vp4 Vp5* domain <br /> | |||
**[[3gzt]], [[3gzu]] – rrVCP Vp7 – Cryo EM<BR /> | **[[3gzt]], [[3gzu]] – rrVCP Vp7 – Cryo EM<BR /> | ||
**[[ | **[[1kqr]], [[3tb0]] – rrVCP Vp4 Vp8* domain + neuraminic acid derivative <BR /> | ||
**[[3tay]] – prVCP Vp4 Vp8* domain (mutant) + neuraminic acid derivative <BR /> | |||
**[[2i2s]] - VCP Vp4 Vp8* domain – pig rotavirus<br /> | |||
**[[3sis]], [[3sit]] - prVCP Vp4 Vp8* domain + glycan<br /> | |||
**[[2dwr]] - hrvVCP Vp8* – human rotavirus<br /> | **[[2dwr]] - hrvVCP Vp8* – human rotavirus<br /> | ||
**[[4drr]], [[4drv]], [[4ds0]] - hrvVCP Vp8* + antigen | **[[4drr]], [[4drv]], [[4ds0]] - hrvVCP Vp4 Vp8* domain + antigen | ||
*Virus coat protein of hepatitis virus | *Virus coat protein of hepatitis virus | ||