Villin: Difference between revisions
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<StructureSection load='2k6n' size='340' side='right' caption='Human supervillin headpiece, [[2k6n]]' scene='Villin/Cv/1' > | <StructureSection load='2k6n' size='340' side='right' caption='Human supervillin headpiece, [[2k6n]]' scene='Villin/Cv/1' > | ||
== Function == | |||
* [[Villin]] (VIL) is an actin-binding protein. It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin<ref>PMID:10480879</ref>.<br /> | * [[Villin]] (VIL) is an actin-binding protein. It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin<ref>PMID:10480879</ref>.<br /> | ||
* '''Supervillin (SVIL)''' contains numerous gelsolin-like domains in its C-terminal and interacts with actin.<br /> | * '''Supervillin (SVIL)''' contains numerous gelsolin-like domains in its C-terminal and interacts with actin.<br /> | ||
* '''Advillin (AVIL)''' is another actin-binding protein in the [[gelsolin]] superfamily which is expressed in the peripheral sensory neurons.<br /> | * '''Advillin (AVIL)''' is another actin-binding protein in the [[gelsolin]] superfamily which is expressed in the peripheral sensory neurons.<br /> | ||
* '''Cytovillin (CVIL) or ezrin or villin-2''' serves as intermediate between plasma membrane and actin cytoskeleton. | * '''Cytovillin (CVIL) or ezrin or villin-2''' serves as intermediate between plasma membrane and actin cytoskeleton. | ||
== Relevance == | |||
VIL immunohisochemistry is a reliable method for diagnosing microvillus inclusion disease (MVID)<ref>PMID:25517957</ref>. | |||
</StructureSection> | </StructureSection> | ||
== 3D Structures of Villin == | == 3D Structures of Villin == | ||