Uridylate kinase: Difference between revisions
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<StructureSection load='2j4k' size='340' side='right' caption='Uridylate kinase hexamer complex with ligand UMP (stick model), Cd+ (gold) and Mg+2 (green) ions [[2j4k]]' scene='' > | |||
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'''Uridylate kinase''' (UK) catalyzes the reversible transfer of phosphate from UMP to UDP using ATP as a phosphate source. UDP is the starting point of synthesis of all other pyrimidine nucleotides. The eukaryotic UK has specificity to both UMP and CMP while the bacterial one is specific for UMP. The bacterial UK is Mg+2 dependent and is activated by GTP and repressed by UTP. The bacterial UK is composed of a C terminal ATP-binding domain and an N terminal UMP-binding domain. | '''Uridylate kinase''' (UK) catalyzes the reversible transfer of phosphate from UMP to UDP using ATP as a phosphate source. UDP is the starting point of synthesis of all other pyrimidine nucleotides. The eukaryotic UK has specificity to both UMP and CMP while the bacterial one is specific for UMP. The bacterial UK is Mg+2 dependent and is activated by GTP and repressed by UTP. The bacterial UK is composed of a C terminal ATP-binding domain and an N terminal UMP-binding domain<ref>PMID:15454079</ref>. | ||
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==3D structures of uridylate kinase== | ==3D structures of uridylate kinase== | ||
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**[[4a7x]], [[4a7w]] - UK + UDP – ''Helicobacter pylori''<br /> | **[[4a7x]], [[4a7w]] - UK + UDP – ''Helicobacter pylori''<br /> | ||
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==References== | |||
<references /> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 11:27, 11 December 2016
Uridylate kinase (UK) catalyzes the reversible transfer of phosphate from UMP to UDP using ATP as a phosphate source. UDP is the starting point of synthesis of all other pyrimidine nucleotides. The eukaryotic UK has specificity to both UMP and CMP while the bacterial one is specific for UMP. The bacterial UK is Mg+2 dependent and is activated by GTP and repressed by UTP. The bacterial UK is composed of a C terminal ATP-binding domain and an N terminal UMP-binding domain[1]. |
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3D structures of uridylate kinase3D structures of uridylate kinase
Updated on 11-December-2016
ReferencesReferences
- ↑ Dhar G, Sanders ER, Johnson RC. Architecture of the hin synaptic complex during recombination: the recombinase subunits translocate with the DNA strands. Cell. 2004 Oct 1;119(1):33-45. PMID:15454079 doi:http://dx.doi.org/10.1016/j.cell.2004.09.010