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==Substrate-directed dual catalysis of dicarbonyl compounds by diketoreductase== | ==Substrate-directed dual catalysis of dicarbonyl compounds by diketoreductase== | ||
<StructureSection load='4e13' size='340' side='right' caption='[[4e13]], [[Resolution|resolution]] 2.08Å' scene=''> | <StructureSection load='4e13' size='340' side='right' caption='[[4e13]], [[Resolution|resolution]] 2.08Å' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dyd|4dyd]], [[4e12|4e12]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dyd|4dyd]], [[4e12|4e12]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e13 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e13 RCSB], [http://www.ebi.ac.uk/pdbsum/4e13 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e13 OCA], [http://pdbe.org/4e13 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4e13 RCSB], [http://www.ebi.ac.uk/pdbsum/4e13 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4e13 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4e13" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 05:52, 11 December 2016
Substrate-directed dual catalysis of dicarbonyl compounds by diketoreductaseSubstrate-directed dual catalysis of dicarbonyl compounds by diketoreductase
Structural highlights
Publication Abstract from PubMedDiketoreductase catalyzes a two-step bioreduction on a dicarbonyl substrate through a novel dual catalysis mode, in which random hydride attack simultaneously forms two mono-carbonyl intermediates, and subsequently distinct catalytic sites are responsible for the reductions of respective carbonyl group of the intermediates to yield the final dihydroxy product. Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase.,Lu M, Huang Y, White MA, Wu X, Liu N, Cheng X, Chen Y Chem Commun (Camb). 2012 Oct 24;48(92):11352-4. doi: 10.1039/c2cc36334h. PMID:23073461[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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