5for: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 5for is ON HOLD  until Paper Publication
==Cryptic TIR==
 
<StructureSection load='5for' size='340' side='right' caption='[[5for]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
Authors: Halabi, S., Gay, N.J., Moncrieffe, M.C.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5for]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FOR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FOR FirstGlance]. <br>
Description: Cryptic TIR
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=I3C:5-AMINO-2,4,6-TRIIODOBENZENE-1,3-DICARBOXYLIC+ACID'>I3C</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5for FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5for OCA], [http://pdbe.org/5for PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5for RCSB], [http://www.ebi.ac.uk/pdbsum/5for PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5for ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/BCAP_HUMAN BCAP_HUMAN]] Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.<ref>PMID:15893754</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Gay, N J]]
[[Category: Halabi, S]]
[[Category: Halabi, S]]
[[Category: Moncrieffe, M.C]]
[[Category: Moncrieffe, M C]]
[[Category: Gay, N.J]]
[[Category: Cell cycle]]
[[Category: Immume response]]
[[Category: Tir]]

Revision as of 05:11, 11 December 2016

Cryptic TIRCryptic TIR

Structural highlights

5for is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
NonStd Res:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BCAP_HUMAN] Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.[1]

References

  1. ↑ Maruoka M, Suzuki J, Kawata S, Yoshida K, Hirao N, Sato S, Goff SP, Takeya T, Tani K, Shishido T. Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinases. FEBS Lett. 2005 Jun 6;579(14):2986-90. PMID:15893754 doi:http://dx.doi.org/S0014-5793(05)00528-4

5for, resolution 2.50Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=5for&oldid=2696419"