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==Crystal structure of [L-Ala51/51']HIV-1 protease with reduced isostere MVT-101 inhibitor== | ==Crystal structure of [L-Ala51/51']HIV-1 protease with reduced isostere MVT-101 inhibitor== | ||
<StructureSection load='3haw' size='340' side='right' caption='[[3haw]], [[Resolution|resolution]] 1.30Å' scene=''> | <StructureSection load='3haw' size='340' side='right' caption='[[3haw]], [[Resolution|resolution]] 1.30Å' scene=''> | ||
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fsm|3fsm]], [[3gi0|3gi0]], [[3hau|3hau]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fsm|3fsm]], [[3gi0|3gi0]], [[3hau|3hau]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3haw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3haw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3haw RCSB], [http://www.ebi.ac.uk/pdbsum/3haw PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3haw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3haw OCA], [http://pdbe.org/3haw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3haw RCSB], [http://www.ebi.ac.uk/pdbsum/3haw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3haw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3haw" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
Revision as of 23:29, 9 December 2016
Crystal structure of [L-Ala51/51']HIV-1 protease with reduced isostere MVT-101 inhibitorCrystal structure of [L-Ala51/51']HIV-1 protease with reduced isostere MVT-101 inhibitor
Structural highlights
Publication Abstract from PubMedWe have used chemical protein synthesis and advanced physical methods to probe dynamics-function correlations for the HIV-1 protease, an enzyme that has received considerable attention as a target for the treatment of AIDS. Chemical synthesis was used to prepare a series of unique analogues of the HIV-1 protease in which the flexibility of the "flap" structures (residues 37-61 in each monomer of the homodimeric protein molecule) was systematically varied. These analogue enzymes were further studied by X-ray crystallography, NMR relaxation, and pulse-EPR methods, in conjunction with molecular dynamics simulations. We show that conformational isomerization in the flaps is correlated with structural reorganization of residues in the active site, and that it is preorganization of the active site that is a rate-limiting factor in catalysis. Protein conformational dynamics in the mechanism of HIV-1 protease catalysis.,Torbeev VY, Raghuraman H, Hamelberg D, Tonelli M, Westler WM, Perozo E, Kent SB Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):20982-7. Epub 2011 Dec 8. PMID:22158985[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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