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==CRYSTAL STRUCTURES OF PENICILLIN ACYLASE ENZYME-SUBSTRATE COMPLEXES: STRUCTURAL INSIGHTS INTO THE CATALYTIC MECHANISM==
 
==Crystal structures of penicillin acylase enzyme-substrate complexes: Structural insights into the catalytic mechanism==
<StructureSection load='1gkf' size='340' side='right' caption='[[1gkf]], [[Resolution|resolution]] 1.41&Aring;' scene=''>
<StructureSection load='1gkf' size='340' side='right' caption='[[1gkf]], [[Resolution|resolution]] 1.41&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1gkf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GKF FirstGlance]. <br>
<table><tr><td colspan='2'>[[1gkf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GKF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SME:METHIONINE+SULFOXIDE'>SME</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SME:METHIONINE+SULFOXIDE'>SME</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ai4|1ai4]], [[1ai5|1ai5]], [[1ai6|1ai6]], [[1ai7|1ai7]], [[1ajn|1ajn]], [[1ajp|1ajp]], [[1ajq|1ajq]], [[1cp9|1cp9]], [[1e3a|1e3a]], [[1fxh|1fxh]], [[1fxv|1fxv]], [[1gk9|1gk9]], [[1pnk|1pnk]], [[1pnl|1pnl]], [[1pnm|1pnm]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ai4|1ai4]], [[1ai5|1ai5]], [[1ai6|1ai6]], [[1ai7|1ai7]], [[1ajn|1ajn]], [[1ajp|1ajp]], [[1ajq|1ajq]], [[1cp9|1cp9]], [[1e3a|1e3a]], [[1fxh|1fxh]], [[1fxv|1fxv]], [[1gk9|1gk9]], [[1pnk|1pnk]], [[1pnl|1pnl]], [[1pnm|1pnm]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Penicillin_amidase Penicillin amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.11 3.5.1.11] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Penicillin_amidase Penicillin amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.11 3.5.1.11] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gkf OCA], [http://pdbe.org/1gkf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gkf RCSB], [http://www.ebi.ac.uk/pdbsum/1gkf PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gkf OCA], [http://pdbe.org/1gkf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gkf RCSB], [http://www.ebi.ac.uk/pdbsum/1gkf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gkf ProSAT]</span></td></tr>
</table>
</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
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     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gkf ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Penicillin amidase]]
[[Category: Penicillin amidase]]
[[Category: Brannigan, J A]]
[[Category: Brannigan, J A]]
[[Category: Dodson, G G]]
[[Category: Dodson, G G]]
[[Category: Mcvey, C E]]
[[Category: McVey, C E]]
[[Category: Walsh, M A]]
[[Category: Walsh, M A]]
[[Category: Wilson, K S]]
[[Category: Wilson, K S]]
[[Category: Antibiotic resistance]]
[[Category: Antibiotic resistance]]
[[Category: Hydrolase]]

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