User:Kerry Frattarola/Sandbox 1: Difference between revisions

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==Human Immunodeficiency Virus protease inhibitor==

<~~StructureSection~~ load=~~'2b7z'~~ size=~~'340' side~~='right' caption=~~'Structure of HIV-1 protease bound to indinavir~~, ([[~~2b7z~~]])~~, [[Resolution|resolution]] 2.20Å' scene=''~~>

==Structure==

[[Crixivan]] is an antiviral compound that acts as a protease inhibitor. The ~~drug~~ has a molecular weight of 711.875 g/mol and is very soluble in water and ethanol <ref>Physicians Desk Reference 66th ed. PDR Network, LLC, Montvale, NJ. p. 2086 (2012)</ref>. Crixivan works by specifically binding to the HIV-1 protease active site by mimicking a target substrate protein and essentially becoming “stuck” in the enzyme active site, disabling the enzyme. The pyridine group on ~~Crixivan~~ interacts with Arg8 in the protease to conform ~~Crixivan~~ to the active site. The ~~ketone~~ is attacked by the Asp25 of the protease, ~~forming a~~ bond ~~between the ketone and amide that~~ doesn't lyse due to the ~~nature~~ of the ~~inhibitor~~.

[[Crixivan]], also known as Indinavir, is an antiviral compound that acts as a protease inhibitor. The <scene name='74/745991/Crixivan/2'>structure</scene> has a molecular weight of 711.875 g/mol and is very soluble in water and ethanol <ref>Physicians Desk Reference 66th ed. PDR Network, LLC, Montvale, NJ. p. 2086 (2012)</ref>. Crixivan works by specifically binding to the HIV-1 protease active site by mimicking a target substrate protein and essentially becoming “stuck” in the enzyme active site, disabling the enzyme. The pyridine group on Indinavir interacts with Arg8 in the protease to conform Indinavir to the active site. The amide is attacked by the Asp25 of the protease, however the peptide bond doesn't lyse due to the stability of the molecule.

== Function ==

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 ==Human Immunodeficiency Virus protease inhibitor==
-<StructureSection load='2b7z' size='340' side='right' caption='Structure of HIV-1 protease bound to indinavir, ([[2b7z]]), [[Resolution|resolution]] 2.20&Aring;' scene=''>
+<applet   load="" size="350" color="" frame="true"  spin="on" Scene ="Indinavir/Indinavir/1" align="right" caption="Crixivan, also known as Indinavir, ([[1hsg]])"/>
 ==Structure==
-[[Crixivan]] is an antiviral compound that acts as a protease inhibitor. The drug has a molecular weight of 711.875 g/mol and is very soluble in water and ethanol <ref>Physicians Desk Reference 66th ed. PDR Network, LLC, Montvale, NJ. p. 2086 (2012)</ref>. Crixivan works by specifically binding to the HIV-1 protease active site by mimicking a target substrate protein and essentially becoming “stuck” in the enzyme active site, disabling the enzyme. The pyridine group on Crixivan interacts with Arg8 in the protease to conform Crixivan to the active site. The ketone is attacked by the Asp25 of the protease, forming a bond between the ketone and amide that doesn't lyse due to the nature of the inhibitor.
+[[Crixivan]], also known as Indinavir, is an antiviral compound that acts as a protease inhibitor. The <scene name='74/745991/Crixivan/2'>structure</scene> has a molecular weight of 711.875 g/mol and is very soluble in water and ethanol <ref>Physicians Desk Reference 66th ed. PDR Network, LLC, Montvale, NJ. p. 2086 (2012)</ref>. Crixivan works by specifically binding to the HIV-1 protease active site by mimicking a target substrate protein and essentially becoming “stuck” in the enzyme active site, disabling the enzyme. The pyridine group on Indinavir interacts with Arg8 in the protease to conform Indinavir to the active site. The amide is attacked by the Asp25 of the protease, however the peptide bond doesn't lyse due to the stability of the molecule.
 == Function ==