User:Kerry Frattarola/Sandbox 1: Difference between revisions

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==Structure==

[[Crixivan]] is an antiviral compound that acts as a protease inhibitor. The drug has a molecular weight of 711.875 g/mol and is very soluble in water and ethanol <ref>Physicians Desk Reference 66th ed. PDR Network, LLC, Montvale, NJ. p. 2086 (2012)</ref>. Crixivan works by specifically binding to the HIV-1 protease active site by mimicking a target substrate protein and essentially becoming “stuck” in the enzyme active site, disabling the enzyme. The pyridine group on ~~Indinavir~~ interacts with Arg8 in the protease to conform ~~Indinavir~~ to the active site. The ketone is attacked by with the Asp25 of the protease, forming a bond between the ketone and amide doesn't lyse due to the nature of the inhibitor.

[[Crixivan]] is an antiviral compound that acts as a protease inhibitor. The drug has a molecular weight of 711.875 g/mol and is very soluble in water and ethanol <ref>Physicians Desk Reference 66th ed. PDR Network, LLC, Montvale, NJ. p. 2086 (2012)</ref>. Crixivan works by specifically binding to the HIV-1 protease active site by mimicking a target substrate protein and essentially becoming “stuck” in the enzyme active site, disabling the enzyme. The pyridine group on Crixivan interacts with Arg8 in the protease to conform Crixivan to the active site. The ketone is attacked by with the Asp25 of the protease, forming a bond between the ketone and amide that doesn't lyse due to the nature of the inhibitor.

== Function ==

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 ==Structure==
-[[Crixivan]] is an antiviral compound that acts as a protease inhibitor. The drug has a molecular weight of 711.875 g/mol and is very soluble in water and ethanol <ref>Physicians Desk Reference 66th ed. PDR Network, LLC, Montvale, NJ. p. 2086 (2012)</ref>. Crixivan works by specifically binding to the HIV-1 protease active site by mimicking a target substrate protein and essentially becoming “stuck” in the enzyme active site, disabling the enzyme. The pyridine group on Indinavir interacts with Arg8 in the protease to conform Indinavir to the active site. The ketone is attacked by with the Asp25 of the protease, forming a bond between the ketone and amide doesn't lyse due to the nature of the inhibitor.
+[[Crixivan]] is an antiviral compound that acts as a protease inhibitor. The drug has a molecular weight of 711.875 g/mol and is very soluble in water and ethanol <ref>Physicians Desk Reference 66th ed. PDR Network, LLC, Montvale, NJ. p. 2086 (2012)</ref>. Crixivan works by specifically binding to the HIV-1 protease active site by mimicking a target substrate protein and essentially becoming “stuck” in the enzyme active site, disabling the enzyme. The pyridine group on Crixivan interacts with Arg8 in the protease to conform Crixivan to the active site. The ketone is attacked by with the Asp25 of the protease, forming a bond between the ketone and amide that doesn't lyse due to the nature of the inhibitor.
 == Function ==