Ubiquitin conjugating enzyme

Function Ubiquitin conjugating enzyme (Ubc) or E2 enzyme catalyzes the second step in the ubiquitination of a protein tagged to be degraded by the proteasome. Ubiquitin activating enzyme (E1) and ATP produce a C-terminal acyl adenylated ubiquitin molecule which binds to ubiquitin conjugating enzyme (E2) (Ubc) cysteine. The Ubc then binds to ubiquitin ligase (E3) via a conserved binding region. E3 catalyzes the transfer of ubiquitin from the Ubc-ubiquitin complex to a lysine residue of the target protein. Ubc13 makes a catalytically active heterodimer with MMS2. For more details on Ubc13 see UBC13 MMS2. For more details on Ubc9 see Ubc9. Structural highlights The active site of Ubc contains a cysteine residue. The .

spinqualitylabelsall models Structure of human ubiquitin conjugating enzyme E2 (green) complex with ubiquitin (deepskyblue) (PDB entry 3ptf) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of ubiquitin conjugating enzyme3D Structures of ubiquitin conjugating enzyme

Updated on 05-December-2016

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• Ubiquitin conjugating enzyme
  • 2aak – AtUbc – Arabidopsis thaliana
    
  • 2e2c – Ubc – Spisula solidissima
    
  • 1q34 – CeUbc – Caenorhabidis elegans
    
  • 2qcq, 1fzy – yUbc – yeast
    
  • 1jas – hUbc – human
    
  • 2fo3 – Ubc – Plasmodium vivax
    
  • 2h2y – PfUbc – Plasmodium falciparum
    
  • 1fxt – yUbc + ubiquitin
    
• Ubiquitin conjugating enzyme 1
  • 1tte – yUbc (mutant)
    
  • 2aak – AtUbc
    
  • 1z3d – CeUbc
    
  • 3we5 – Ubc – poplar mushroom
    
• Ubiquitin conjugating enzyme 2
  • 1ayz – yUbc
    
  • 1z2u – CeUbc
    
  • 4r62 – yUbc + ubiquitin carboxyl extension protein 80
    
• Ubiquitin conjugating enzyme 4
  • 1qcq – yUbc
    
  • 4ii2 – Ubc (mutant) + E1 + ATP – fission yeast
    
  • 5aie – yUbc + NOT4 RING domain
    
• Ubiquitin conjugating enzyme 5
  • 2esk, 2clw, 3l1y, 3tgd, 2c4p, 1x23 – hUbc
    
  • 2eso, 2esp, 2esq – hUbc (mutant)
    
  • 1w4u – hUbc - NMR
    
• Ubiquitin conjugating enzyme 5 complexes
  • 1ur6 – hUbc + Cnot4 - NMR
    
  • 3eb6 – Ubc + baculoviral IAP repeat-containing protein- frog
    
  • 4auq – hUbc (mutant) + baculoviral IAP repeat-containing protein + ubiquitin
    
  • 3ptf, 4ddg, 4ddi – hUbc + ubiquitin
    
  • 2fuh – hUbc + ubiquitin - NMR
    
  • 3a33, 3ugb – hUbc (mutant) + ubiquitin
    
  • 3jvz, 3jw0 – hUbc (mutant) + E3 NEDD4-2 + ubiquitin
    
  • 4ap4 – hUbc + E3 Rnf4 + ubiquitin
    
  • 3oj4 – hUbc + tumor necrosis factor α-induced protein 3 + ubiquitin
    
  • 4a49 – hUbc + E3 Cbl
    
  • 4a4b, 4a4c – hUbc + E3 Cbl + ZAP-70 peptide
    
  • 3l1z – hUbc + ubiquitin conjugating factor
    
  • 3rpg – hUbc + E3 Ring2 + polycomb complex protein Bmi-1
    
  • 3zni – hUbc + ubiquitin + + E3 Cbl + ZAP-70 peptide
    
• Ubiquitin conjugating enzyme 6
  • 4jjq – hUbc + ubiquitin carboxyl terminal hydrolase
    
• Ubiquitin conjugating enzyme 7 or Ubc L3
  • 2ucz – yUbc
    
  • 2awf, 2cyx – hUbc
    
  • 1c4z – hUbc + E3 HECT domain
    
  • 1fbv – hUbc + E3 Cbl + ZAP-70 peptide
    
  • 4jqu – hUbc + U7BR
    
  • 3sqv – hUbc + secreted effector protein
    
  • 3sy2 – hUbc + E3 Sopa
    
  • 4q5e, 4q5h – hUbc (mutant) + ubiquitin + OspG
    
  • 5hpt – hUbc + ubiquitin + NEDD4-like E3 ubiquitin-protein
    
• Ubiquitin conjugating enzyme 8
  • 1y6l, 1wzw, 1wzv – hUbc
    
  • 2kjh – hUbc + ubiquitin
    
  • 4x57 – AtUbc + membrane-anchord ubiquitin-fold protein
    
• Ubiquitin conjugating enzyme 9 see SUMO conjugating enzyme Ubc9
• Ubiquitin conjugating enzyme 10 or Ubc C
  • 1i7k – hUbc (mutant)
    
  • 4yii – hUbc + anaphase-promoting complex subunit 2
    
• Ubiquitin conjugating enzyme 12 (NEDD8 conjugating enzyme; Ubc F)
  • 3o2u – yUbc
    
  • 1tt5 – hUbc + E1 Uba3, APPBP1 subunits
    
  • 1y8x – hUbc + E1 NEDD8
    
  • 2nvu – hUbc + E1 NEDD8 + NEDD8
    
  • 3fn1 – hUbc + E1 NEDD8-activating enzyme
    
  • 3tdu – hUbc + cullin-1 + Dcn1-like protein
    
  • 4gao – hUbc + Dcn1-like protein
    
  • 3tdi – hUbc + defective in cullin neddylation protein
    
• Ubiquitin conjugating enzyme 13 or Ubc N
  • 1jbb – yUbc
    
  • 1jat – yUbc/Mms2
    
  • 1j74 – hMms2
    
  • 1j7d – hUbc/Mms2
    
  • 4onl, 4onm, 4onn – hUbc + Mms2 (mutant)
    
  • 4nr3, 4nrg, 4nri – hUbc (mutant) + Mms2
    
  • 4fh1 – hUbc (mutant)
    
• Ubiquitin conjugating enzyme 13 complexes
  • 2c2v – hUbc + CHIP + Uev1a
    
  • 3hct, 3hcu – hUbc + TNF receptor associated factor 6
    
  • 4dhi – CeUbc + OTUB1
    
  • 4dhi, 4dhz – hUbc + OTUB1 + ubiquitin + ubiquitin aldehyde
    
  • 4orh – hUbc/Mms2 + E3 Rnf8
    
  • 3von – hUbc/Mms2 + OTUB1
    
  • 1zgu – hMms2 + ubiquitin - NMR
    
  • 5eya – hUbc + ubiquitin + TRIM25 ring domain
    
  • 4tkp – hUbc + TRIM5 ring domain
    
  • 2gmi – hUbc/Mms2 (mutant) + ubiquitin
    
  • 4dhj – hUbc + ubiquitin + OTUB1
    
  • 4whv – hUbc + ubiquitin + E3 ubiquitin-protein ligase RNF8
    
  • 5ait, 5aiu – hUbc + ubiquitin + E3 ubiquitin-protein ligase RNF4
    
  • 4orh – hUbc/Mms2 + E3 ubiquitin-protein ligase RN8
    
  • 4ip3, 3w31 – hUbc + Orf169b
    
  • 2oxq – Ubc + CHIP U-box - zebrafish
    
• Ubiquitin conjugating enzyme 16 or Ubc W
  • 2mt6 – hUbc - NMR
    
• Ubiquitin conjugating enzyme B
  • 2yb6 – hUbc
    
  • 2y4w – hUbc - NMR
    
  • 2ybf – hUbc + Rad18
    
• Ubiquitin conjugating enzyme D
  • 2yho – hUbc D1 + E3 Mylip
    
  • 5fer – hUbc D1 + ubiquitin carboxyl extension protein 80 + TRIM25 ring
    
  • 4qpl – hUbc D1 + E3 ubiquitin-protein ligase RNF146
    
  • 4ldt – hUbc D2 + OTUB1 + ubiquitin
    
  • 5d1k, 5d1l, 5d1m – hUbc D2 + E3 ubiquitin-protein ligase RNF25
    
  • 5edv – hUbc D2 + ubiquitin + E3 ubiquitin-protein ligase RNF31
    
  • 4v3k, 4v3l – hUbc D2 + ubiquitin + E3 ubiquitin-protein ligase RNF38
    
  • 5d0k, 5d0m – hUbc D2 + ubiquitin + RING finger protein 165
    
  • 4wz3 – hUbc D2 + E3 ubiquitin-protein ligase LubX
    
  • 5egg – hUbc D3
    
  • 5ifr – hUbc D3 + ubiquitin
    
  • 4s3o – hUbc D3 + polycomb group ring finger protein + E3 ubiquitin-protein ligase RING2
    
  • 4bvu – hUbc D3 + OspG + ubiquitin
    
• Ubiquitin conjugating enzyme E1
  • 3bzh – hUbc
    
• Ubiquitin conjugating enzyme G2
  • 3fsh – hUbc + autocrine motility factor receptor
    
  • 2kly – hUbc - NMR
    
  • 2lxp – hUbc + AMFR peptide - NMR
    
  • 3h8k, 4lad – hUbc + AMFR peptide
    
• Ubiquitin conjugating enzyme H
  • 2z5d – hUbc
    
• Ubiquitin conjugating enzyme J2
  • 2f4w – hUbc
    
• Ubiquitin conjugating enzyme K
  • 5dfl – hUbc + ubiquitin
    
• Ubiquitin conjugating enzyme Q
  • 2qgx – hUbc
    
• Ubiquitin conjugating enzyme R1
  • 3rz3 – hUbc + inhibitor
    
  • 4mdk – hUbc + ubiquitin + inhibitor
    
• Ubiquitin conjugating enzyme S
  • 1zdn – hUbc
    
  • 5bnb – hUbc + ubiquitin
    
• Ubiquitin conjugating enzyme T
  • 4ccg – hUbc + E3 ubiquitin-protein ligase Fancl
    
• Ubiquitin conjugating enzyme Uev-1
  • 2a4d – hUbc catalytic domain
    
  • 2hlw – hUbc catalytic domain - NMR
    
  • 3e95 – PfUbc + ubiquitin carrier protein
    
• Ubiquitin conjugating enzyme Z
  • 5a4p – hUbc
    
• Ubiquitin conjugating enzyme E2-25KDa (Huntington interacting protein 2 HIP-2)
  • 1yla, 2bep – hHIP-2
    
  • 3e46 – hHIP-2 (mutant)
    
  • 2bf8 – hHIP-2 + SUMO
    
  • 2o25 – hHIP-2 + Ubc9
    
  • 3f92 – hHIP-2/azorectase (mutant)
    
  • 3k9o, 3k9p – hHIP-2 + ubiquitin