Carbidopa: Difference between revisions

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== Disease in Humans ==
== Disease in Humans ==
Parkinson's disease (PD) is a chronic, progressive neurological disease whose symptoms include bradykinesia, tremors, postural instability and rigidity. Although the exact cause of the disease is currently unknown, it is believe to be caused by the apoptosis of dopanergic cells in the substantia nigra of the brain and subsequent loss of dopamine.<ref name="seven">PMID:10746727</ref>Carbidopa is mostly related to people with Parkinson’s disease. According to the National Parkinson Foundation, Levodopa alone is known to cause nausea and vomiting in Parkinson’s patients, and Carbidopa prevents those side effects. Carbidopa can act as an enhancer for Levodopa by decreasing the dosage of Levodopa needed for Parkinson’s patients, about 80%. Current treatments for Parkinson’s disease are combined tablet of Carbidopa and Levodopa (Sinemet), which are offered as immediate-release tablets and slow-release tablets, along with dissolvable tablets.
Parkinson's disease (PD) is a chronic, progressive neurological disease whose symptoms include bradykinesia, tremors, postural instability and rigidity. Although the exact cause of the disease is currently unknown, it is believe to be caused by the apoptosis of dopanergic cells in the substantia nigra of the brain and subsequent loss of dopamine.<ref name="seven">PMID:10746727</ref>Carbidopa is mostly related to people with Parkinson’s disease. According to the National Parkinson Foundation, Levodopa alone is known to cause nausea and vomiting in Parkinson’s patients, and Carbidopa prevents those side effects.<ref name="eight">http://www.parkinson.org/understanding-parkinsons/treatment/Medications-for-Motor-Symptoms/Carbidopa-levodopa</ref> Carbidopa can act as an enhancer for Levodopa by decreasing the dosage of Levodopa needed for Parkinson’s patients, about 80%. Current treatments for Parkinson’s disease are combined tablet of Carbidopa and Levodopa (Sinemet), which are offered as immediate-release tablets and slow-release tablets, along with dissolvable tablets.<ref name="nine">http://www.merck.com/product/home.html</ref>
 
<ref name="eleven">PMID:18828673</ref>




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Andrew Warzinski, Victoria Markunas