User:Kerry Frattarola/Sandbox 1

Human Immunodeficiency Virus protease inhibitorHuman Immunodeficiency Virus protease inhibitor

spinqualitylabelsall models Indinavir, better known as Crixivan, (1hsg) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=> Structure Indinavir is an antiviral compound that acts as a protease inhibiter. Figure 2 below depicts Indinavir’s structure. The drug has a molecular weight of 711.875 g/mol and is very soluble in water and ethanol . Indinavir works by specifically binding to the HIV-1 protease active site by mimicking a target substrate protein and essentially becoming “stuck” in the enzyme active site, disabling the enzyme. Indinavir’s pyridine attracts protease Arg8 to hold it in place. It's ketone interacts with the protease Asp25 to perform initiate aspartic catalysis. The bond between the ketone and amine doesn't lyse due to the nature of the inhibitor. Mechanism Indinavir acts with the Asp25, Thr26 and Gly27 subunits in the HIV-1 protease enzyme.

spinqualitylabelsall models Structure of HIV-1 protease mutant bound to indinavir, (2b7z), resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image