User:Andrew Nguyen/Sandbox 1: Difference between revisions
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== Structural Highlights == | == Structural Highlights == | ||
Januvia is an aromatic compound with a terminal polar <scene name='74/745984/Tfp/3'>trifluorophenyl group</scene> and a <scene name='74/745984/Tfm/1'>trifluoromethyl group</scene>. The enzyme DPP-4 consists of a <scene name='Sitagliptin/Hdryo/1'>hydrophobic serine (S1) pocket</scene> and other <scene name='Sitagliptin/Hbond/2'>hydrogen bonding residues</scene>. Residues of importance for binding purposes between the enzyme DPP-4 and Januvia include the <scene name='Sitagliptin/Bound/1'>catalytic triad</scene> (Ser630, His740, and Asp708) and two glutamates (Glu205 and Glu206).<ref name= "PDB">Ghosh, S. & Goodsell, D. Dipeptidyl Peptidase 4: Protein Data Bank (PDB). (2016) | Januvia is an aromatic compound with a terminal polar <scene name='74/745984/Tfp/3'>trifluorophenyl group</scene> and a <scene name='74/745984/Tfm/1'>trifluoromethyl group</scene>. The enzyme DPP-4 consists of a <scene name='Sitagliptin/Hdryo/1'>hydrophobic serine (S1) pocket</scene> and other <scene name='Sitagliptin/Hbond/2'>hydrogen bonding residues</scene>. Residues of importance for binding purposes between the enzyme DPP-4 and Januvia include the <scene name='Sitagliptin/Bound/1'>catalytic triad</scene> (Ser630, His740, and Asp708) and two glutamates (Glu205 and Glu206).<ref name= "PDB">Ghosh, S. & Goodsell, D. Dipeptidyl Peptidase 4: Protein Data Bank (PDB). (2016) | ||
[http://dx.doi | [http://dx.doi.org/10.2210/rcsb_pdb/mom_2016_10 doi:10.2210/rcsb_pdb/mom_2016_10]</ref> | ||
== Function == | == Function == | ||