Collagenase (non-MMP): Difference between revisions

Revision as of 14:38, 14 November 2016

Collagenase (Col) catalyzes the breaking of peptide bonds in collagen. Col cleaves pro-collagen to create collagen. Some collagenases are part of the Matrix metalloproteinase family.

Relevance

Col is used for therapy of wounds, Dupuytren's contracture and Peyronie's disease.

Structural highlights

Clostridium histolycum collagenase contains several domains among them: peptidase domain (residues 331-721), polycystic kidney disease domain (PKD residues 792-880), collagen-binding domain (CBD residues 1003-1118). The peptidase domain contains a , a and an .^[1] .

Collagenase H peptidase domain (cyan) complex with peptidic inhibitor, isopentenyl phosphate, Ca+2 (green) and Zn+2 (grey) ions (PDB entry 4arf)

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3D Structures of collagenase3D Structures of collagenase

Updated on 14-November-2016

ReferencesReferences

↑ Eckhard U, Schonauer E, Brandstetter H. Structural basis for activity regulation and substrate preference of clostridial collagenases G, H, and T. J Biol Chem. 2013 May 23. PMID:23703618 doi:10.1074/jbc.M112.448548

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Michal Harel, Alexander Berchansky

[1] Eckhard U, Schonauer E, Brandstetter H. Structural basis for activity regulation and substrate preference of clostridial collagenases G, H, and T. J Biol Chem. 2013 May 23. PMID:23703618 doi:10.1074/jbc.M112.448548

[1]

@@ Line 23: / Line 23: @@
 **[[4are]] - ChColG residues 119-790<br />
 **[[2y6i]] - ChColG residues 119-880 + peptide<br />
-**[[4jrw]], [[4tn9]], [[3jqu]], [[3js7]], [[4aqo]], [[2y72]] - ChColG PKD domain<br />
+**[[4jrw]], [[4tn9]], [[4aqo]], [[2y72]] - ChColG PKD domain<br />
 **[[1nqj]] - ChColG CBD domain <br />
 **[[1nqd]], [[2o8o]], [[4hpk]]- ChColG CBD domain + Ca<br />