Major histocompatibility complex: Difference between revisions
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<StructureSection load='3ox8' size=' | <StructureSection load='3ox8' size='350' side='right' caption='Human MHC class I antigen (cyan) with β 2-microglobulin (green) and peptide from Hepatitis virus (deeppink) [[3ox8]]' scene='45/457390/Cv/1'> | ||
== Function == | == Function == | ||
''' Major Histocompatibility Complex''' (MHC) are part of the cell immune system. MHC molecules display antigens on the host cell’s surface. T cell or natural killer receptors recognize the MHC:peptide and activate the immune response.<br /> | ''' Major Histocompatibility Complex''' (MHC) are part of the cell immune system. MHC molecules display antigens on the host cell’s surface. T cell or natural killer receptors recognize the MHC:peptide and activate the immune response.<br /> | ||
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*MHC I ternary complex | *MHC I ternary complex | ||
**[[ | **[[4d0b]], [[3bew]], [[2yez]], [[5ad0]], [[4d0c]], [[3bev]] – cMHC I α + β-2-microglobulin + peptide<br /> | ||
**[[3kpn]], [[3kpo]] – hMHC I B + β-2-microglobulin + peptide<br /> | **[[3kpn]], [[3kpo]] – hMHC I B + β-2-microglobulin + peptide<br /> | ||
**[[3bev]], [[1kpr]], [[1k5n]], [[3nfn]], [[3mr9]], [[3mrb]], [[3mrc]], [[3mrd]], [[3mre]], [[3mrf]], [[3mrg]], [[3mrh]], [[3mri]], [[3mrj]], [[3mrk]], [[3mrl]], [[3mrm]], [[3mrn]], [[3mro]], [[3mrp]], [[3mrq]], [[3mrr]], [[3ox8]], [[3oxr]], [[3oxs]], [[2xpg]], [[3pwj]], [[3pwl]], [[3pwn]], [[3pwp]], [[2x70]], [[3o3a]], [[3o3b]], [[3o3d]], [[3o3e]], [[3lv3]], [[3ln4]], [[3ln5]], [[3myj]], [[3i6l]], [[3lkn]], [[3lko]], [[3lkp]], [[3lkq]], [[3lkr]], [[3lks]], [[3hpj]], [[3i6g]], [[3i6k]], [[3mgo]], [[3mgt]], [[3l3d]], [[3l3g]], [[3l3i]], [[3l3j]], [[3l3k]], [[2x4n]], [[2x4o]], [[2x4p]], [[2x4q]], [[2x4r]], [[2x4s]], [[2x4t]], [[2x4u]], [[3lka]], [[3h7b]], [[3kpl]], [[3kpm]], [[3kpn]], [[3kpo]], [[3kpp]], [[3kpq]], [[3kpr]], [[3kps]], [[3giv]], [[3hcv]], [[3d18]], [[3dtx]], [[3czf]], [[3fqn]], [[3fqr]], [[3fqt]], [[3fqu]], [[3fqw]], [[3fqx]], [[3d25]], [[3bvn]], [[3dx6]], [[3dx7]], [[3dx8]], [[3dxa]], [[3bo8]], [[3bp4]], [[3bp7]], [[3bgm]], [[3bh8]], [[3bh9]], [[3bhb]], [[3b3i]], [[3b6s]], [[2rfx]], [[3bze]], [[3bzf]], [[3bw9]], [[3bwa]], [[3c9n]], [[2v2w]], [[2v2x]], [[2gt9]], [[2gtw]], [[2gtz]], [[2guo]], [[2nw3]], [[2fyy]], [[2fz3]], [[2hn7]], [[2cik]], [[2git]], [[2hjk]], [[2hjl]], [[2h6p]], [[2d31]], [[2c7u]], [[2bck]], [[2a83]], [[2axf]], [[2axg]], [[2bvo]], [[2bvp]], [[2bvq]], [[1s8d]], [[1t1w]], [[1t1x]], [[1t1y]], [[1t1z]], [[1t20]], [[1t21]], [[1t22]], [[1s7q]], [[1zsd]], [[2bsr]], [[2bss]], [[2bst]], [[1zhk]], [[1zhl]], [[1tvb]], [[1tvh]], [[1xr8]], [[1xr9]], [[1w0v]], [[1w0w]], [[1xh3]], [[1uxs]], [[1uxw]], [[1s9w]], [[1s9x]], [[1s9y]], [[1q94]], [[1qvo]], [[1n2r]], [[1ogt]], [[1qew]], [[1jge]], [[1k5n]], [[1i7r]], [[1i7t]], [[1i7u]], [[1jf1]], [[1jht]], [[1i4f]], [[1e27]], [[1e28]], [[1i1y]], [[1i1f]], [[1qqd]], [[1mhe]], [[1b0g]], [[1a9b]], [[1a9e]], [[1a1m]], [[1a1n]], [[1a1o]], [[1tmc]], [[2clr]], [[1hhg]], [[1hhh]], [[1hhi]], [[1hhj]], [[1hhk]], [[1hsb]], [[1hsa]], [[3to2]], [[2vab]] - hMHC I α + β-2-microglobulin + peptide<br /> | **[[3bev]], [[1kpr]], [[1k5n]], [[3nfn]], [[3mr9]], [[3mrb]], [[3mrc]], [[3mrd]], [[3mre]], [[3mrf]], [[3mrg]], [[3mrh]], [[3mri]], [[3mrj]], [[3mrk]], [[3mrl]], [[3mrm]], [[3mrn]], [[3mro]], [[3mrp]], [[3mrq]], [[3mrr]], [[3ox8]], [[3oxr]], [[3oxs]], [[2xpg]], [[3pwj]], [[3pwl]], [[3pwn]], [[3pwp]], [[2x70]], [[3o3a]], [[3o3b]], [[3o3d]], [[3o3e]], [[3lv3]], [[3ln4]], [[3ln5]], [[3myj]], [[3i6l]], [[3lkn]], [[3lko]], [[3lkp]], [[3lkq]], [[3lkr]], [[3lks]], [[3hpj]], [[3i6g]], [[3i6k]], [[3mgo]], [[3mgt]], [[3l3d]], [[3l3g]], [[3l3i]], [[3l3j]], [[3l3k]], [[2x4n]], [[2x4o]], [[2x4p]], [[2x4q]], [[2x4r]], [[2x4s]], [[2x4t]], [[2x4u]], [[3lka]], [[3h7b]], [[3kpl]], [[3kpm]], [[3kpn]], [[3kpo]], [[3kpp]], [[3kpq]], [[3kpr]], [[3kps]], [[3giv]], [[3hcv]], [[3d18]], [[3dtx]], [[3czf]], [[3fqn]], [[3fqr]], [[3fqt]], [[3fqu]], [[3fqw]], [[3fqx]], [[3d25]], [[3bvn]], [[3dx6]], [[3dx7]], [[3dx8]], [[3dxa]], [[3bo8]], [[3bp4]], [[3bp7]], [[3bgm]], [[3bh8]], [[3bh9]], [[3bhb]], [[3b3i]], [[3b6s]], [[2rfx]], [[3bze]], [[3bzf]], [[3bw9]], [[3bwa]], [[3c9n]], [[2v2w]], [[2v2x]], [[2gt9]], [[2gtw]], [[2gtz]], [[2guo]], [[2nw3]], [[2fyy]], [[2fz3]], [[2hn7]], [[2cik]], [[2git]], [[2hjk]], [[2hjl]], [[2h6p]], [[2d31]], [[2c7u]], [[2bck]], [[2a83]], [[2axf]], [[2axg]], [[2bvo]], [[2bvp]], [[2bvq]], [[1s8d]], [[1t1w]], [[1t1x]], [[1t1y]], [[1t1z]], [[1t20]], [[1t21]], [[1t22]], [[1s7q]], [[1zsd]], [[2bsr]], [[2bss]], [[2bst]], [[1zhk]], [[1zhl]], [[1tvb]], [[1tvh]], [[1xr8]], [[1xr9]], [[1w0v]], [[1w0w]], [[1xh3]], [[1uxs]], [[1uxw]], [[1s9w]], [[1s9x]], [[1s9y]], [[1q94]], [[1qvo]], [[1n2r]], [[1ogt]], [[1qew]], [[1jge]], [[1k5n]], [[1i7r]], [[1i7t]], [[1i7u]], [[1jf1]], [[1jht]], [[1i4f]], [[1e27]], [[1e28]], [[1i1y]], [[1i1f]], [[1qqd]], [[1mhe]], [[1b0g]], [[1a9b]], [[1a9e]], [[1a1m]], [[1a1n]], [[1a1o]], [[1tmc]], [[2clr]], [[1hhg]], [[1hhh]], [[1hhi]], [[1hhj]], [[1hhk]], [[1hsb]], [[1hsa]], [[3to2]], [[2vab]] - hMHC I α + β-2-microglobulin + peptide<br /> | ||
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**[[1kjv]], [[1kjm]], [[1ed3]] – MHC I α + β-2-microglobulin + peptide - rat<br /> | **[[1kjv]], [[1kjm]], [[1ed3]] – MHC I α + β-2-microglobulin + peptide - rat<br /> | ||
**[[2oi9]] - mMHC I α + T cell receptor + peptide<br /> | **[[2oi9]] - mMHC I α + T cell receptor + peptide<br /> | ||
**[[1kbg]], [[3l3h]], [[3ftg]], [[3e6f]], [[3ecb]], [[3ch1]], [[3cch]], [[3cc5]], [[3cpl]], [[2zsv]], [[2zsw]], [[2zok]], [[2zol]], [[3buy]], [[2ve6]], [[2e7l]], [[2fo4]], [[2cii]], [[2fwo]], [[2f74]], [[1zt1]], [[1zt7]], [[1vgk]], [[1yn6]], [[1yn7]], [[1zhb]], [[1wbx]], [[1wby]], [[1wbz]], [[1rjy]], [[1rjz]], [[1rk0]], [[1rk1]], [[1t0m]], [[1t0n]], [[1s7q]], [[1s7r]], [[1s7s]], [[1s7t]], [[1s7u]], [[1s7v]], [[1s7w]], [[1s7x]], [[1lk2]], [[1kpu]], [[1kpv]], [[1n3n]], [[1nan]], [[1n59]], [[1n5a]], [[1ffn]], [[1ffo]], [[1ffp]], [[1g7p]], [[1g7q]], [[1lek]], [[1leg]], [[1inq]], [[1juf]], [[1k8d]], [[1jpf]], [[1jpg]], [[1fg2]], [[1qlf]], [[1bz9]], [[1kbg]], [[1hoc]], [[2mha]], [[1vad]], [[1vac]], [[3roo]], [[3quk]], [[3qul]], [[3rol]], [[3tbs]], [[3tbt]], [[3tbv]], [[3tbw]], [[ | **[[1kbg]], [[3l3h]], [[3ftg]], [[3e6f]], [[3ecb]], [[3ch1]], [[3cch]], [[3cc5]], [[3cpl]], [[2zsv]], [[2zsw]], [[2zok]], [[2zol]], [[3buy]], [[2ve6]], [[2e7l]], [[2fo4]], [[2cii]], [[2fwo]], [[2f74]], [[1zt1]], [[1zt7]], [[1vgk]], [[1yn6]], [[1yn7]], [[1zhb]], [[1wbx]], [[1wby]], [[1wbz]], [[1rjy]], [[1rjz]], [[1rk0]], [[1rk1]], [[1t0m]], [[1t0n]], [[1s7q]], [[1s7r]], [[1s7s]], [[1s7t]], [[1s7u]], [[1s7v]], [[1s7w]], [[1s7x]], [[1lk2]], [[1kpu]], [[1kpv]], [[1n3n]], [[1nan]], [[1n59]], [[1n5a]], [[1ffn]], [[1ffo]], [[1ffp]], [[1g7p]], [[1g7q]], [[1lek]], [[1leg]], [[1inq]], [[1juf]], [[1k8d]], [[1jpf]], [[1jpg]], [[1fg2]], [[1qlf]], [[1bz9]], [[1kbg]], [[1hoc]], [[2mha]], [[1vad]], [[1vac]], [[3roo]], [[3quk]], [[3qul]], [[3rol]], [[3tbs]], [[3tbt]], [[3tbv]], [[3tbw]], [[4nsk]], [[3tby]] - mMHC I + β-2-microglobulin + peptide<br /> | ||
**[[2qri]] - mMHC I/β-2-microglobulin/peptide<br /> | **[[2qri]] - mMHC I/β-2-microglobulin/peptide<br /> | ||
**[[2qrs]], [[2qrt]] - mMHC I (mutant)/β-2-microglobulin/peptide<br /> | **[[2qrs]], [[2qrt]] - mMHC I (mutant)/β-2-microglobulin/peptide<br /> | ||