User:Andrew Nguyen/Sandbox 1: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
Januvia is an aromatic compound with a terminal polar trifluorophenyl group and a trifluoromethyl group. The enzyme DPP-4 consists of a hydrophobic serine (S1) pocket and other hydrogen bonding residues. Residues of importance for binding purposes between the enzyme DPP-4 and Januvia include the catalytic triad (Ser630, His740, and Asp708) and two glutamates (Glu205 and Glu206). <ref>doi:10.2210</ref> | Januvia is an aromatic compound with a terminal polar trifluorophenyl group and a trifluoromethyl group. The enzyme DPP-4 consists of a <scene name='Sitagliptin/Hdryo/1'>hydrophobic serine (S1) pocket</scene> and other hydrogen bonding residues. Residues of importance for binding purposes between the enzyme DPP-4 and Januvia include the catalytic triad (Ser630, His740, and Asp708) and two glutamates (Glu205 and Glu206). <ref>doi:10.2210</ref> | ||
== Function == | == Function == | ||