5eww: Difference between revisions

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'''Unreleased structure'''


The entry 5eww is ON HOLD  until Paper Publication
==Crystal structure of the human BRPF1 bromodomain in complex with SEED21==
 
<StructureSection load='5eww' size='340' side='right' caption='[[5eww]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
Authors: Zhu, J., Wiedmer, L., Caflisch, A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5eww]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EWW FirstGlance]. <br>
Description: Crystal structure of the human BRPF1 bromodomain in complex with SEED21
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5SK:~{N}-[(2~{R})-BUTAN-2-YL]-1-METHYL-[1,2,4]TRIAZOLO[4,3-A]QUINOXALIN-4-AMINE'>5SK</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eww OCA], [http://pdbe.org/5eww PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eww RCSB], [http://www.ebi.ac.uk/pdbsum/5eww PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eww ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Caflisch, A]]
[[Category: Caflisch, A]]
[[Category: Wiedmer, L]]
[[Category: Wiedmer, L]]
[[Category: Zhu, J]]
[[Category: Zhu, J]]
[[Category: Dna binding protein]]
[[Category: Inhibitor]]
[[Category: Transcription]]

Revision as of 21:26, 2 November 2016

Crystal structure of the human BRPF1 bromodomain in complex with SEED21Crystal structure of the human BRPF1 bromodomain in complex with SEED21

Structural highlights

5eww is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.[1] [2]

References

  1. ↑ Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell. 2006 Jan 6;21(1):51-64. PMID:16387653 doi:10.1016/j.molcel.2005.12.007
  2. ↑ Ullah M, Pelletier N, Xiao L, Zhao SP, Wang K, Degerny C, Tahmasebi S, Cayrou C, Doyon Y, Goh SL, Champagne N, Cote J, Yang XJ. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. Mol Cell Biol. 2008 Nov;28(22):6828-43. doi: 10.1128/MCB.01297-08. Epub 2008 Sep , 15. PMID:18794358 doi:10.1128/MCB.01297-08

5eww, resolution 1.73Å

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