5syn: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
m Protected "5syn" [edit=sysop:move=sysop]
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 5syn is ON HOLD  until Paper Publication
==Cocrystal structure of the human acyl protein thioesterase 2 with an isoform-selective inhibitor, ML349==
 
<StructureSection load='5syn' size='340' side='right' caption='[[5syn]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
Authors: Labby, K.J., Stuckey, J.A., Meagher, J.L., Won, S.J., Martin, B.R.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5syn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5SYN FirstGlance]. <br>
Description: Cocrystal structure of the human acyl protein thioesterase 2 with an isoform-selective inhibitor, ML349
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=71T:2-[4-(4-METHOXYPHENYL)PIPERAZINE-1-CARBONYL]-5LAMBDA~6~-THIENO[3,2-C][1]BENZOTHIOPYRAN-5,5(4H)-DIONE'>71T</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5sym|5sym]]</td></tr>
[[Category: Labby, K.J]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5syn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5syn OCA], [http://pdbe.org/5syn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5syn RCSB], [http://www.ebi.ac.uk/pdbsum/5syn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5syn ProSAT]</span></td></tr>
[[Category: Won, S.J]]
</table>
[[Category: Meagher, J.L]]
== Function ==
[[Category: Stuckey, J.A]]
[[http://www.uniprot.org/uniprot/LYPA2_HUMAN LYPA2_HUMAN]] May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has lysophospholipase activity (By similarity). Deacylates GAP43.<ref>PMID:21152083</ref> 
[[Category: Martin, B.R]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Labby, K J]]
[[Category: Martin, B R]]
[[Category: Meagher, J L]]
[[Category: Stuckey, J A]]
[[Category: Won, S J]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Inhibitor]]
[[Category: Thioesterase]]

Revision as of 21:50, 26 October 2016

Cocrystal structure of the human acyl protein thioesterase 2 with an isoform-selective inhibitor, ML349Cocrystal structure of the human acyl protein thioesterase 2 with an isoform-selective inhibitor, ML349

Structural highlights

5syn is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[LYPA2_HUMAN] May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has lysophospholipase activity (By similarity). Deacylates GAP43.[1]

References

  1. ↑ Tomatis VM, Trenchi A, Gomez GA, Daniotti JL. Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43. PLoS One. 2010 Nov 30;5(11):e15045. doi: 10.1371/journal.pone.0015045. PMID:21152083 doi:http://dx.doi.org/10.1371/journal.pone.0015045

5syn, resolution 1.64Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=5syn&oldid=2685141"