5sym: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
m Protected "5sym" [edit=sysop:move=sysop]
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 5sym is ON HOLD
==Cocrystal structure of the human acyl protein thioesterase 1 with an isoform-selective inhibitor, ML348==
 
<StructureSection load='5sym' size='340' side='right' caption='[[5sym]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5sym]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SYM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5SYM FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=71Q:N-[2-CHLORO-5-(TRIFLUOROMETHYL)PHENYL]-2-[4-(FURAN-2-CARBONYL)PIPERAZIN-1-YL]ACETAMIDE'>71Q</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5syn|5syn]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5sym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sym OCA], [http://pdbe.org/5sym PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5sym RCSB], [http://www.ebi.ac.uk/pdbsum/5sym PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5sym ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/LYPA1_HUMAN LYPA1_HUMAN]] Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity and also low lysophospholipase activity.<ref>PMID:20418879</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Labby, K J]]
[[Category: Martin, B R]]
[[Category: Meagher, J L]]
[[Category: Stuckey, J A]]
[[Category: Won, S J]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Inhibitor]]
[[Category: Thioesterase]]

Revision as of 21:49, 26 October 2016

Cocrystal structure of the human acyl protein thioesterase 1 with an isoform-selective inhibitor, ML348Cocrystal structure of the human acyl protein thioesterase 1 with an isoform-selective inhibitor, ML348

Structural highlights

5sym is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[LYPA1_HUMAN] Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity and also low lysophospholipase activity.[1]

References

  1. ↑ Dekker FJ, Rocks O, Vartak N, Menninger S, Hedberg C, Balamurugan R, Wetzel S, Renner S, Gerauer M, Scholermann B, Rusch M, Kramer JW, Rauh D, Coates GW, Brunsveld L, Bastiaens PI, Waldmann H. Small-molecule inhibition of APT1 affects Ras localization and signaling. Nat Chem Biol. 2010 Jun;6(6):449-56. doi: 10.1038/nchembio.362. Epub 2010 Apr 25. PMID:20418879 doi:http://dx.doi.org/10.1038/nchembio.362

5sym, resolution 1.55Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=5sym&oldid=2685140"