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==Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (long unit cell form) - from XFEL diffraction== | |||
<StructureSection load='5kj7' size='340' side='right' caption='[[5kj7]], [[Resolution|resolution]] 3.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5kj7]] is a 11 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KJ7 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kj8|5kj8]]</td></tr> | ||
[[Category: Lyubimov, A | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kj7 OCA], [http://pdbe.org/5kj7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kj7 RCSB], [http://www.ebi.ac.uk/pdbsum/5kj7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kj7 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/SNP25_RAT SNP25_RAT]] t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. [[http://www.uniprot.org/uniprot/VAMP3_RAT VAMP3_RAT]] SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. [[http://www.uniprot.org/uniprot/STX1A_RAT STX1A_RAT]] Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. [[http://www.uniprot.org/uniprot/SYT1_RAT SYT1_RAT]] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Brewster, A S]] | |||
[[Category: Brunger, A T]] | |||
[[Category: Lyubimov, A Y]] | |||
[[Category: Sauter, N K]] | |||
[[Category: Uervirojnangkoorn, M]] | [[Category: Uervirojnangkoorn, M]] | ||
[[Category: Weis, W I]] | |||
[[Category: Zhao, M]] | |||
[[Category: Zhou, Q]] | [[Category: Zhou, Q]] | ||
[[Category: | [[Category: Endocytosis]] | ||
[[Category: | [[Category: Exocytosis]] | ||
[[Category: | [[Category: Neuronal snare complex]] | ||
[[Category: | [[Category: Synaptic fusion complex]] | ||
[[Category: | [[Category: Synaptotagmin1]] | ||
[[Category: Xfel structure]] | |||
Revision as of 04:00, 20 October 2016
Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (long unit cell form) - from XFEL diffractionStructure of the Ca2+-bound synaptotagmin-1 SNARE complex (long unit cell form) - from XFEL diffraction
Structural highlights
Function[SNP25_RAT] t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. [VAMP3_RAT] SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. [STX1A_RAT] Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. [SYT1_RAT] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. |
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