5eet: Difference between revisions

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'''Unreleased structure'''


The entry 5eet is ON HOLD
==Crystal structure of murine neuroglobin at ambient pressure==
 
<StructureSection load='5eet' size='340' side='right' caption='[[5eet]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
Authors: Colloc'h, N., Girard, E., Vallone, B.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5eet]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EET OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EET FirstGlance]. <br>
Description: Crystal structure of murine neuroglobin at ambient pressure
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eet OCA], [http://pdbe.org/5eet PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eet RCSB], [http://www.ebi.ac.uk/pdbsum/5eet PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eet ProSAT]</span></td></tr>
[[Category: Colloc'H, N]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/NGB_MOUSE NGB_MOUSE]] Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.<ref>PMID:11473111</ref> <ref>PMID:11473128</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Girard, E]]
[[Category: Vallone, B]]
[[Category: Vallone, B]]
[[Category: Girard, E]]
[[Category: H, N Colloc]]
[[Category: Globin]]
[[Category: Oxygen storage-transporter]]
[[Category: Transport protein]]

Revision as of 03:56, 20 October 2016

Crystal structure of murine neuroglobin at ambient pressureCrystal structure of murine neuroglobin at ambient pressure

Structural highlights

5eet is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[NGB_MOUSE] Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.[1] [2]

References

  1. ↑ Couture M, Burmester T, Hankeln T, Rousseau DL. The heme environment of mouse neuroglobin. Evidence for the presence of two conformations of the heme pocket. J Biol Chem. 2001 Sep 28;276(39):36377-82. Epub 2001 Jul 25. PMID:11473111 doi:http://dx.doi.org/10.1074/jbc.M103907200
  2. ↑ Dewilde S, Kiger L, Burmester T, Hankeln T, Baudin-Creuza V, Aerts T, Marden MC, Caubergs R, Moens L. Biochemical characterization and ligand binding properties of neuroglobin, a novel member of the globin family. J Biol Chem. 2001 Oct 19;276(42):38949-55. Epub 2001 Jul 25. PMID:11473128 doi:http://dx.doi.org/10.1074/jbc.M106438200

5eet, resolution 2.00Å

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OCA
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