5e0r: Difference between revisions

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-'''Unreleased structure'''
-The entry 5e0r is ON HOLD  until Sep 29 2017
+==Crystal Structure of the first bromodomain of BRD4 in complex with AYC==
+<StructureSection load='5e0r' size='340' side='right' caption='[[5e0r]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
-Authors: Dong, J., Caflisch, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5e0r]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E0R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E0R FirstGlance]. <br>
-Description: Crystal Structure of the first bromodomain of BRD4 in complex with AYC
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5J5:2-[(CHLOROACETYL)AMINO]-5-[(E)-(4-SULFOPHENYL)DIAZENYL]BENZENESULFONIC+ACID'>5J5</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e0r OCA], [http://pdbe.org/5e0r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e0r RCSB], [http://www.ebi.ac.uk/pdbsum/5e0r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e0r ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Caflisch, A]]
 [[Category: Dong, J]]
-[[Category: Caflisch, A]]
+[[Category: Transcription-transcription inhibitor complex]]