5az5: Difference between revisions

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'''Unreleased structure'''


The entry 5az5 is ON HOLD  until Paper Publication
==Crystal structure of human TLR8 in complex with MB-343==
 
<StructureSection load='5az5' size='340' side='right' caption='[[5az5]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
Authors: Tanji, H., Ohto, U., Shimizu, T.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5az5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AZ5 FirstGlance]. <br>
Description: Crystal structure of human TLR8 in complex with MB-343
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MBL:1-PENTYL-4-PHENYL-IMIDAZOL-2-AMINE'>MBL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5az5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5az5 OCA], [http://pdbe.org/5az5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5az5 RCSB], [http://www.ebi.ac.uk/pdbsum/5az5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5az5 ProSAT]</span></td></tr>
[[Category: Tanji, H]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Ohto, U]]
[[Category: Ohto, U]]
[[Category: Shimizu, T]]
[[Category: Shimizu, T]]
[[Category: Tanji, H]]
[[Category: Adjuvant]]
[[Category: Glycosylation]]
[[Category: Immune system]]
[[Category: Innate immunity]]
[[Category: Tlr]]
[[Category: Tlr8]]
[[Category: Vaccine adjuvant]]
[[Category: Viral infection]]

Revision as of 00:21, 6 October 2016

Crystal structure of human TLR8 in complex with MB-343Crystal structure of human TLR8 in complex with MB-343

Structural highlights

5az5 is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TLR8_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.[1]

References

  1. ↑ Doyle SL, Jefferies CA, Feighery C, O'Neill LA. Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. J Biol Chem. 2007 Dec 21;282(51):36953-60. Epub 2007 Oct 11. PMID:17932028 doi:10.1074/jbc.M707682200

5az5, resolution 2.40Å

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OCA
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