5aqo: Difference between revisions

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-'''Unreleased structure'''
-The entry 5aqo is ON HOLD  until Paper Publication
+==Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues==
+<StructureSection load='5aqo' size='340' side='right' caption='[[5aqo]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
-Authors: Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5aqo]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AQO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AQO FirstGlance]. <br>
-Description: Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CWS:6-METHYLQUINAZOLIN-4-AMINE'>CWS</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5aqf|5aqf]], [[5aqg|5aqg]], [[5aqh|5aqh]], [[5aqi|5aqi]], [[5aqj|5aqj]], [[5aqk|5aqk]], [[5aql|5aql]], [[5aqm|5aqm]], [[5aqn|5aqn]], [[5aqp|5aqp]], [[5aqq|5aqq]], [[5aqr|5aqr]], [[5aqs|5aqs]], [[5aqt|5aqt]], [[5aqu|5aqu]], [[5aqv|5aqv]], [[5aqw|5aqw]], [[5aqx|5aqx]], [[5aqy|5aqy]], [[5aqz|5aqz]], [[5ar0|5ar0]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitochondrial_protein-transporting_ATPase Mitochondrial protein-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.51 3.6.3.51] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aqo OCA], [http://pdbe.org/5aqo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aqo RCSB], [http://www.ebi.ac.uk/pdbsum/5aqo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aqo ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/HSP7C_HUMAN HSP7C_HUMAN]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.<ref>PMID:10722728</ref>  [[http://www.uniprot.org/uniprot/BAG1_HUMAN BAG1_HUMAN]] Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.<ref>PMID:9305631</ref> <ref>PMID:9873016</ref> <ref>PMID:12724406</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Mitochondrial protein-transporting ATPase]]
 [[Category: Burke, R]]
-[[Category: Liu, M]]
+[[Category: Cheeseman, M D]]
-[[Category: Van Montfort, R.L.M]]
-[[Category: Lee, D]]
-[[Category: Yahya, N]]
-[[Category: Rowlands, M.G]]
-[[Category: Dobson, S.E]]
 [[Category: Collins, I]]
-[[Category: Workman, P]]
+[[Category: Dobson, S E]]
+[[Category: Jeganathan, F]]
+[[Category: Jones, A M]]
 [[Category: Jones, K]]
-[[Category: Cheeseman, M.D]]
+[[Category: Kadi, N]]
-[[Category: Westwood, I.M]]
+[[Category: Lee, D]]
-[[Category: Mcandrew, C]]
+[[Category: Liu, M]]
-[[Category: Jones, A.M]]
+[[Category: Matthews, T P]]
+[[Category: McAndrew, C]]
+[[Category: Montfort, R L.M van]]
+[[Category: Osborne, J D]]
 [[Category: Richards, M]]
-[[Category: Kadi, N]]
+[[Category: Rowlands, M G]]
-[[Category: Jeganathan, F]]
+[[Category: Westwood, I M]]
-[[Category: Osborne, J.D]]
+[[Category: Workman, P]]
-[[Category: Matthews, T.P]]
+[[Category: Yahya, N]]
+[[Category: Atpase]]
+[[Category: Bag1]]
+[[Category: Chaperone]]
+[[Category: Fragment]]
+[[Category: Heat shock protein]]
+[[Category: Hsc70]]
+[[Category: Hsp70]]
+[[Category: Hsp72]]