Tumor necrosis factor: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
<StructureSection load='2az5' size='350' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene=''> | <StructureSection load='2az5' size='350' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene=''> | ||
== Function == | == Function == | ||
'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). | '''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. '''TNFβ''' is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). | ||
== Relevance == | == Relevance == | ||
| Line 12: | Line 12: | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
*TNF | *TNF α | ||
**[[1tnf]] – hTNF – human <BR /> | **[[1tnf]] – hTNF – human <BR /> | ||
| Line 24: | Line 24: | ||
**[[4twt]] – hTNF + peptide <BR /> | **[[4twt]] – hTNF + peptide <BR /> | ||
*TNF | *TNF β | ||
**[[1tnr]] – hTNF + TNF receptor p55 <BR /> | **[[1tnr]] – hTNF + TNF receptor p55 <BR /> | ||