Tryptophan RNA-binding attenuation protein: Difference between revisions

Revision as of 11:23, 27 September 2016

Function

Tryptophan RNA-binding attenuation protein (TRAP) is a tryptophan-activated RNA-binding protein which regulates the expression of the tryptophan biosynthesis genes. Down regulation of Trp biosynthesis is observed upon binding of 11 Trp to TRAP^[1].

Structural highlights

TRAP is composed of 11 identical subunits arranged in a symmetrical ring. Tryptophan is bound to TRAP by mostly non-polar residues^[2].

Structure of tryptophan RNA-binding attenuation protein complex with Trp (PDB code 2exs).

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3D Structures of tryptophan RNA-binding attenuation protein3D Structures of tryptophan RNA-binding attenuation protein

Updated on 27-September-2016

ReferencesReferences

↑ Li PT, Gollnick P. Characterization of a trp RNA-binding attenuation protein (TRAP) mutant with tryptophan independent RNA binding activity. J Mol Biol. 2004 Jan 16;335(3):707-22. PMID:14687568 doi:http://dx.doi.org/10.1016/S0022283603013846
↑ Heddle JG, Yokoyama T, Yamashita I, Park SY, Tame JR. Rounding up: Engineering 12-membered rings from the cyclic 11-mer TRAP. Structure. 2006 May;14(5):925-33. PMID:16698553 doi:http://dx.doi.org/10.1016/j.str.2006.03.013

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Li PT, Gollnick P. Characterization of a trp RNA-binding attenuation protein (TRAP) mutant with tryptophan independent RNA binding activity. J Mol Biol. 2004 Jan 16;335(3):707-22. PMID:14687568 doi:http://dx.doi.org/10.1016/S0022283603013846

[2] Heddle JG, Yokoyama T, Yamashita I, Park SY, Tame JR. Rounding up: Engineering 12-membered rings from the cyclic 11-mer TRAP. Structure. 2006 May;14(5):925-33. PMID:16698553 doi:http://dx.doi.org/10.1016/j.str.2006.03.013

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 == Function ==
-'''Tryptophan RNA-binding attenuation protein''' (TRAP) is a tryptophan-activated RNA-binding protein which regulates the expression of the tryptophan biosynthesis genes.  TRAP is composed of 11 identical subunits arranged in a symmetrical ring.  Down regulation of Trp biosynthesis is observed upon binding of 11 Trp to TRAP<ref>PMID:14687568</ref>.
+'''Tryptophan RNA-binding attenuation protein''' (TRAP) is a tryptophan-activated RNA-binding protein which regulates the expression of the tryptophan biosynthesis genes.  Down regulation of Trp biosynthesis is observed upon binding of 11 Trp to TRAP<ref>PMID:14687568</ref>.
 == Structural highlights ==
-Tryptophan is bound to TRAP by mostly non-polar residues<ref>PMID:16698553</ref>.
+TRAP is composed of 11 identical subunits arranged in a symmetrical ring.  Tryptophan is bound to TRAP by mostly non-polar residues<ref>PMID:16698553</ref>.
 </StructureSection>