Troponin: Difference between revisions
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{{STRUCTURE_1yv0| PDB=1yv0 | SIZE=400| SCENE=Troponin/Cv/1 |right|CAPTION=Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]] }} | {{STRUCTURE_1yv0| PDB=1yv0 | SIZE=400| SCENE=Troponin/Cv/1 |right|CAPTION=Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]] }} | ||
== Function == | |||
[[Troponin]] (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:<br /> | [[Troponin]] (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:<br /> | ||
* '''TnC''' causes conformational change in TnI when it binds to calcium ions. For more details on TnC see<br /> | * '''TnC''' causes conformational change in TnI when it binds to calcium ions<ref>PMID:26232335</ref>. For more details on TnC see<br /> | ||
[[ Role of Troponin C in decreased muscle sensitivity to calcium]]<br /> | [[ Role of Troponin C in decreased muscle sensitivity to calcium]]<br /> | ||
[[Human Cardiac Troponin C]]<br /> | [[Human Cardiac Troponin C]]<br /> | ||
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* '''TnT''' binds to [[Tropomyosin|tropomyosin]].<br /> | * '''TnT''' binds to [[Tropomyosin|tropomyosin]].<br /> | ||
* '''TnI''' binds to actin which is found in thin muscle filaments.<br /> | * '''TnI''' binds to actin which is found in thin muscle filaments.<br /> | ||
== Disease == | |||
Mutations in TnI<ref>PMID:9241277</ref> and TnT <ref>PMID:11606294</ref>are associated with hypertrophic cardiomyopathy. | |||
== 3D Structures of Troponin == | == 3D Structures of Troponin == | ||
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**[[2z5h]] – yTnT fragment+tropomyosin – yeast | **[[2z5h]] – yTnT fragment+tropomyosin – yeast | ||
}} | }} | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||