Trichodiene synthase: Difference between revisions

Revision as of 12:20, 22 September 2016

Function

Trichodiene synthase (TCS) catalyzes the conversion of trans,trans-farnesyl diphosphate to trichodiene and diphosphate (PP). TCS belongs to the family of sesquiterpene syntases which cyclize the acyclic farnesyl diphosphate to a sesquiterpene. TCS contains metal ion-binding motif^[1].

Structural highlights

Trichodiene synthase complex with diphosphate, competitive inhibitor and Mg+2 ion (green) 2q9y

Drag the structure with the mouse to rotate

3D Structures of trichodiene synthase3D Structures of trichodiene synthase

Updated on 22-September-2016

1jfa – FsTCS – Fusarium sporotrichioides
1kiy, 1yj4, 2ps6 – FsTCS (mutant)
2aek, 2ps4, 2ps7 – FsTCS (mutant) + Mg
1jfg, 2q9z – FsTCS + PP + Mg
1kiz, 1yyq, 2ps5, 2ps8 – FsTCS (mutant) + PP + Mg
1yyr, 1yys, 1yyt, 1yyu, 2ael, 2aet – FsTCS (mutant) + PP + Mg + azabisabolene
2q9y – FsTCS + PP + Mg + benzyl triethyl ammonium

ReferencesReferences

↑ Bardot O, Clemencet MC, Passilly P, Latruffe N. The analysis of modified peroxisome proliferator responsive elements of the peroxisomal bifunctional enzyme in transfected HepG2 cells reveals two regulatory motifs. FEBS Lett. 1995 Feb 27;360(2):183-6. PMID:7875326

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Bardot O, Clemencet MC, Passilly P, Latruffe N. The analysis of modified peroxisome proliferator responsive elements of the peroxisomal bifunctional enzyme in transfected HepG2 cells reveals two regulatory motifs. FEBS Lett. 1995 Feb 27;360(2):183-6. PMID:7875326

[1]

@@ Line 1: / Line 1: @@
-{{STRUCTURE_2q9z|  PDB=2q9z  | SIZE=350| SCENE= |right|CAPTION=Trichodiene synthase complex with diphosphate and Mg+2 ion (green) [[2q9z]] }}
+<StructureSection load='2q9y' size='340' side='right' caption='Trichodiene synthase complex with diphosphate, competitive inhibitor and Mg+2 ion (green) [[2q9y]]' scene=''>
+== Function ==
+'''Trichodiene synthase''' (TCS) catalyzes the conversion of trans,trans-farnesyl diphosphate to trichodiene and diphosphate (PP).  TCS belongs to the family of sesquiterpene syntases which cyclize the acyclic farnesyl diphosphate to a sesquiterpene.  TCS contains metal ion-binding motif<ref>PMID:7875326</ref>.
-'''Trichodiene synthase''' (TCS) catalyzes the conversion of trans,trans-farnesyl diphosphate to trichodiene and diphosphate (PP).  TCS belongs to the family of sesquiterpene syntases which cyclize the acyclic farnesyl diphosphate to a Sesquiterpene.  TCS contains metalion-binding motifs.
+== Structural highlights ==
+</StructureSection>
 == 3D Structures of trichodiene synthase ==
@@ Line 15: / Line 19: @@
 [[1yyr]], [[1yys]], [[1yyt]], [[1yyu]], [[2ael]], [[2aet]] – FsTCS (mutant) + PP + Mg + azabisabolene<br />
 [[2q9y]] – FsTCS + PP + Mg + benzyl triethyl ammonium<br />
+== References ==
+<references/>