Thymidylate kinase: Difference between revisions
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<StructureSection load='1e99' size='350' side='right' scene='' caption='Human thymidylate kinase complex with HIV prodrug AZTP, ADP (stick model) and Mg+2 ion (green)'> | |||
== Function == | == Function == | ||
'''Thymidylate kinase''' (TMK) catalyzes the conversion of thymidine-5’-phosphate (dTMP) and ATP to thymidine-5’-diphosphate and ADP. TMK is important for DNA synthesis<ref>PMID:23394555</ref>. Inhibitors of TMK include bisubstrate compounds of the type TP(n)X where P(n) are the number of phosphoryl groups and X is the nucleoside moiety of the acceptor. For more details see [[Student Project 8 for UMass Chemistry 423 Spring 2015]]. | '''Thymidylate kinase''' (TMK) catalyzes the conversion of thymidine-5’-phosphate (dTMP) and ATP to thymidine-5’-diphosphate and ADP. TMK is important for DNA synthesis<ref>PMID:23394555</ref>. Inhibitors of TMK include bisubstrate compounds of the type TP(n)X where P(n) are the number of phosphoryl groups and X is the nucleoside moiety of the acceptor. For more details see [[Student Project 8 for UMass Chemistry 423 Spring 2015]]. | ||
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== Structural highlights == | == Structural highlights == | ||
The active site of TMK contains HIV prodrug azido-thymidine, ADP and Mg+2 ion<ref>PMID:11071809</ref>. | The active site of TMK contains HIV prodrug azido-thymidine, ADP and Mg+2 ion<ref>PMID:11071809</ref>. | ||
</StructureSection> | |||
== 3D Structures of thymidylate kinase == | == 3D Structures of thymidylate kinase == | ||