Toll-like Receptors: Difference between revisions
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*'''TLR2''' is likely involved in specific B cell-mediated functions<ref>PMID:16766226</ref>.<br /> | *'''TLR2''' is likely involved in specific B cell-mediated functions<ref>PMID:16766226</ref>.<br /> | ||
*'''TLR4''' is the central lipid recognition protein in the lipopolysaccharide receptor complex<ref>PMID:10683379</ref>.<br /> | *'''TLR4''' is the central lipid recognition protein in the lipopolysaccharide receptor complex<ref>PMID:10683379</ref>.<br /> | ||
*'''TLR6''' is involved in the discrimination of bacterial lipoproteins by the immune system<ref>PMID:11431423</ref>.<br /> | |||
*'''TLR8''' is linked to the control of CD4+ regulatory T cells<ref>PMID:16123302</ref>.<br /> | *'''TLR8''' is linked to the control of CD4+ regulatory T cells<ref>PMID:16123302</ref>.<br /> | ||
*'''TLR10''' see [[:Category:Toll-like receptor 10|Toll-like receptor 10]]. | *'''TLR9''' is involved in the activation of innate immunity<ref>PMID:12243247</ref>.<br /> | ||
*'''TLR10''' see [[:Category:Toll-like receptor 10|Toll-like receptor 10]].<br /> | |||
*'''TLR13''' is activated by a motif in bacterial ribosome 23S RNA and is not present in human<ref>PMID:25225249</ref>.<br /> | |||
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**[[3a7b]] - mTLR2/VLRB.61 – mouse<br /> | **[[3a7b]] - mTLR2/VLRB.61 – mouse<br /> | ||
**[[3a7c]] - mTLR2/VLRB.61 + PE-DTPA<br /> | **[[3a7c]] - mTLR2/VLRB.61 + PE-DTPA<br /> | ||
**[[3a79]] – hTLR2/VLRB.61 + hTLR6/VLRB.61 + lipopeptide | **[[3a79]] – hTLR2/VLRB.61 + hTLR6/VLRB.61 + lipopeptide<br /> | ||
**[[5d3i]] – mTLR2 + SSL3<br /> | |||
*Toll-like receptor 3 | *Toll-like receptor 3 | ||
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**[[1ziw]], [[2a0z]] – hTLR3 ligand-binding domain<br /> | **[[1ziw]], [[2a0z]] – hTLR3 ligand-binding domain<br /> | ||
**[[3cig]] – mTLR3 ectodomain<br /> | **[[3cig]] – mTLR3 ectodomain<br /> | ||
**[[3ciy]] - mTLR3 ectodomain + RNA | **[[3ciy]] - mTLR3 ectodomain + RNA<br /> | ||
**[[2mk9]], [[2mka]] – hTLR3 transmembrane domain - NMR <br /> | |||
*Toll-like receptor 4 | *Toll-like receptor 4 | ||
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**[[3fxi]], [[4g8a]] - hTLR4 extracellular domain + lymphocyte antigen 96<br /> | **[[3fxi]], [[4g8a]] - hTLR4 extracellular domain + lymphocyte antigen 96<br /> | ||
**[[3ula]] - hTLR4/VLRB.61 + lymphocyte antigen 96<br /> | **[[3ula]] - hTLR4/VLRB.61 + lymphocyte antigen 96<br /> | ||
*Toll-like receptor 6 | |||
**[[4om7]] – hTLR6 TIR domain <br /> | |||
*Toll-like receptor 8 | *Toll-like receptor 8 | ||
**[[3w3g]] – hTLR8 <br /> | **[[3w3g]], [[5hdh]] – hTLR8 <br /> | ||
**[[3w3j]], [[3w3k]], [[3w3l]], [[3w3m]], [[3w3n]], [[3wn4]] – hTLR8 + agonist<br /> | **[[3w3j]], [[3w3k]], [[3w3l]], [[3w3m]], [[3w3n]], [[3wn4]], [[5awa]], [[5awc]], [[5awb]], [[5awd]], [[4r6a]], [[4qbz]], [[4qc0]] – hTLR8 + agonist<br /> | ||
**[[4r07]], [[4r09]] – hTLR8 + ORN06 <br /> | |||
**[[4r08]] – hTLR8 + RNA <br /> | |||
**[[4r0a]] – hTLR8 + uridine <br /> | |||
*Toll-like receptor 9 | |||
**[[3wpb]] – hoTLR9 - horse <br /> | |||
**[[3wpc]], [[3wpd]], [[3wpe]] – hoTLR9 + DNA <br /> | |||
**[[3wpf]] – mTLR9 <br /> | |||
**[[3wpg]], [[3wph]], [[3wpi]] – mTLR9 + DNA <br /> | |||
*Toll-like receptor 10 | *Toll-like receptor 10 | ||
**[[2j67]] – hTLR10 TIR domain | **[[2j67]] – hTLR10 TIR domain | ||
*Toll-like receptor 13 | |||
**[[4z0c]] – mTLR13 + RNA <br /> | |||
}} | }} | ||