Toll-like Receptors: Difference between revisions
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== Function == | == Function == | ||
'''Toll-like receptors''', often abbreviated TLRs, are found on the surface of phagocytic cells of vertebrates and invertebrates and are critical to the innate immune system. The Toll-like receptors recognize molecular patterns associated with pathogens, such as double-stranded RNA, lipopolysaccharide, or CpG DNA, and initiate an intracellular kinase cascade, inducing an immediate defensive response.<ref>PMID: 20084417</ref><ref>PMID: 18064347</ref> See [[Inflammation & Rheumatoid Arthritis]]. The receptors are multi-domain structures consisting of an extracellular ectodomain, a transmembrane domain and a intracellular Toll/IL-1 receptor domain. The extracellular domains contain [[leucine-rich repeats]]. | '''Toll-like receptors''', often abbreviated TLRs, are found on the surface of phagocytic cells of vertebrates and invertebrates and are critical to the innate immune system. The Toll-like receptors recognize molecular patterns associated with pathogens, such as double-stranded RNA, lipopolysaccharide, or CpG DNA, and initiate an intracellular kinase cascade, inducing an immediate defensive response.<ref>PMID: 20084417</ref><ref>PMID: 18064347</ref> See [[Inflammation & Rheumatoid Arthritis]]. The receptors are multi-domain structures consisting of an extracellular ectodomain, a transmembrane domain and a intracellular Toll/IL-1 receptor domain. The extracellular domains contain [[leucine-rich repeats]]. | ||
*'''TLR2''' is likely involved in specific B cell-mediated functions<ref>PMID:16766226</ref>. | |||
*'''TLR4''' is the central lipid recognition protein in the lipopolysaccharide receptor complex<ref>PMID:10683379</ref>. | |||
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*[[:Category:Toll like receptor adaptor domain|Toll like receptor adaptor domain]] | *[[:Category:Toll like receptor adaptor domain|Toll like receptor adaptor domain]] | ||
*[[:Category:Tlr|TLR]] | *[[:Category:Tlr|TLR]] | ||
== Relevance == | |||
A variant of TLR3 confers protection agains geographical atrophy<ref>PMID:218753640</ref>. TLR3 is activated during viral infection<ref>PMID:23864690</ref>. | |||
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