5dhs: Difference between revisions

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'''Unreleased structure'''


The entry 5dhs is ON HOLD  until Paper Publication
==Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a novel inhibitor==
 
<StructureSection load='5dhs' size='340' side='right' caption='[[5dhs]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
Authors: Gelin, M., Paoletti, J., Assairi, L., Huteau, V., Pochet, S., Labesse, G.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5dhs]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DHS FirstGlance]. <br>
Description: Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a novel inhibitor
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5AG:5-AZIDO-5-DEOXY-8-[(2-{[2-(3-ETHYNYLPHENYL)ETHYL]AMINO}-2-OXOETHYL)SULFANYL]ADENOSINE'>5AG</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5dhu|5dhu]], [[5dht|5dht]], [[5dhr|5dhr]], [[5dhq|5dhq]], [[5dhp|5dhp]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_kinase NAD(+) kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.23 2.7.1.23] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dhs OCA], [http://pdbe.org/5dhs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dhs RCSB], [http://www.ebi.ac.uk/pdbsum/5dhs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dhs ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/NADK1_LISMO NADK1_LISMO]] Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.[HAMAP-Rule:MF_00361]<ref>PMID:17686780</ref> <ref>PMID:22608967</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Assairi, L]]
[[Category: Gelin, M]]
[[Category: Huteau, V]]
[[Category: Huteau, V]]
[[Category: Labesse, G]]
[[Category: Labesse, G]]
[[Category: Assairi, L]]
[[Category: Paoletti, J]]
[[Category: Pochet, S]]
[[Category: Pochet, S]]
[[Category: Paoletti, J]]
[[Category: Tetrameric nad kinase]]
[[Category: Gelin, M]]
[[Category: Transferase]]

Revision as of 18:28, 14 September 2016

Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a novel inhibitorCrystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a novel inhibitor

Structural highlights

5dhs is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Activity:NAD(+) kinase, with EC number 2.7.1.23
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[NADK1_LISMO] Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.[HAMAP-Rule:MF_00361][1] [2]

References

  1. ↑ Poncet-Montange G, Assairi L, Arold S, Pochet S, Labesse G. NAD kinases use substrate-assisted catalysis for specific recognition of NAD. J Biol Chem. 2007 Nov 23;282(47):33925-34. Epub 2007 Aug 8. PMID:17686780 doi:10.1074/jbc.M701394200
  2. ↑ Gelin M, Poncet-Montange G, Assairi L, Morellato L, Huteau V, Dugue L, Dussurget O, Pochet S, Labesse G. Screening and In Situ Synthesis Using Crystals of a NAD Kinase Lead to a Potent Antistaphylococcal Compound. Structure. 2012 May 16. PMID:22608967 doi:10.1016/j.str.2012.03.024

5dhs, resolution 2.62Å

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