1os9: Difference between revisions

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|PDB= 1os9 |SIZE=350|CAPTION= <scene name='initialview01'>1os9</scene>, resolution 1.85&Aring;
|PDB= 1os9 |SIZE=350|CAPTION= <scene name='initialview01'>1os9</scene>, resolution 1.85&Aring;
|SITE=  
|SITE=  
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65]  
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] </span>
|GENE= MMP12 OR HME ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= MMP12 OR HME ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|DOMAIN=
|RELATEDENTRY=[[1jk3|1JK3]], [[1os2|1OS2]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1os9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1os9 OCA], [http://www.ebi.ac.uk/pdbsum/1os9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1os9 RCSB]</span>
}}
}}


'''Binary enzyme-product complexes of human MMP12'''
'''Binary enzyme-product complexes of human MMP12'''


==Disease==
Known diseases associated with this structure: Cardiomyopathy, dilated, 1G OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Cardiomyopathy, familial hypertrophic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Muscular dystrophy, limb-girdle, type 2J OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Myopathy, early-onset, with fatal cardiomyopathy OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Myopathy, proximal, with early respiratory muscle involvement OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Tibial muscular dystrophy, tardive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]]


==About this Structure==
==About this Structure==
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[[Category: Mangani, S.]]
[[Category: Mangani, S.]]
[[Category: Terni, B.]]
[[Category: Terni, B.]]
[[Category: CA]]
[[Category: ZN]]
[[Category: complex (elastase/inhibitor)]]
[[Category: complex (elastase/inhibitor)]]
[[Category: elastase]]
[[Category: elastase]]
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[[Category: mmp12]]
[[Category: mmp12]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:14:56 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:49:38 2008''

Revision as of 22:49, 30 March 2008

File:1os9.jpg


PDB ID 1os9

Drag the structure with the mouse to rotate
, resolution 1.85Å
Ligands: ,
Gene: MMP12 OR HME (Homo sapiens)
Activity: Macrophage elastase, with EC number 3.4.24.65
Related: 1JK3, 1OS2


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Binary enzyme-product complexes of human MMP12


About this StructureAbout this Structure

1OS9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

X-ray structures of binary and ternary enzyme-product-inhibitor complexes of matrix metalloproteinases., Bertini I, Calderone V, Fragai M, Luchinat C, Mangani S, Terni B, Angew Chem Int Ed Engl. 2003 Jun 16;42(23):2673-6. PMID:12813751

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