Thymidylate kinase: Difference between revisions
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{{STRUCTURE_1e99| PDB=1e99 | SIZE=350| SCENE= |right|CAPTION=Human thymidylate kinase complex with HIV prodrug AZTP, ADP (stick model) and Mg+2 ion (green) [[1e99]] }} | {{STRUCTURE_1e99| PDB=1e99 | SIZE=350| SCENE= |right|CAPTION=Human thymidylate kinase complex with HIV prodrug AZTP, ADP (stick model) and Mg+2 ion (green) [[1e99]] }} | ||
== Function == | |||
'''Thymidylate kinase''' (TMK) catalyzes the conversion of thymidine-5’-phosphate (dTMP) and ATP to thymidine-5’-diphosphate and ADP. TMK is important for DNA synthesis<ref>PMID:23394555</ref>. Inhibitors of TMK include bisubstrate compounds of the type TP(n)X where P(n) are the number of phosphoryl groups and X is the nucleoside moiety of the acceptor. For more details see [[Student Project 8 for UMass Chemistry 423 Spring 2015]]. | |||
== Relevance == | |||
The TMK inhibitor azido-dTMP (AZTP) is an HIV AZT prodrug metabolite<ref>PMID:15722537</ref>. Inhibitors of TMK are used as antibacterial agents<ref>PMID:23043329</ref>. | |||
== 3D Structures of thymidylate kinase == | == 3D Structures of thymidylate kinase == | ||
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**[[1e9a]] – hTMK (mutant) + azido-TP5A + ADP<br /> | **[[1e9a]] – hTMK (mutant) + azido-TP5A + ADP<br /> | ||
}} | }} | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||