Thioredoxin: Difference between revisions
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[[Thioredoxin]] (Trx) is an enzyme which facilitates the reduction of proteins by cysteine thiol-disulfide exchange. They contain a CXXC motif.<br /> | == Function == | ||
[[Thioredoxin]] (Trx) is an enzyme which facilitates, in its reduced form, the reduction of proteins by cysteine thiol-disulfide exchange<ref>PMID:3152490</ref>. They contain a CXXC motif.<br /> | |||
* '''Trx-1''' is a mammalian cellular protein.<br /> | * '''Trx-1''' is a mammalian cellular protein.<br /> | ||
* '''Trx-2''' is mitochondria-specific.<br /> | * '''Trx-2''' is mitochondria-specific.<br /> | ||
In higher plants, Trx are divided to 6 groups based on their sequence. Trx M, X and Y are found in prokaryotes while F, H and O are found in eukaryotes. | In higher plants, Trx are divided to 6 groups based on their sequence. Trx M, X and Y are found in prokaryotes while F, H and O are found in eukaryotes. | ||
== Relevance == | |||
Serum Trx level is a predictor of steatohepatitis<ref>PMID:12480557</ref>. | |||
== Disease == | |||
Trx is involved in a wide range of human diseases and conditions including cancer, viral diseases, aging, cardiac conditions and more<ref>PMID:15990177</ref>. | |||
== Structural highlights == | |||
== 3D Structures of Thioredoxin == | == 3D Structures of Thioredoxin == | ||
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**[[1dby]] – CrTrx M – NMR<br /> | **[[1dby]] – CrTrx M – NMR<br /> | ||
}} | }} | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||