Thiol:disulfide interchange protein: Difference between revisions
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<StructureSection load='1eej' size='340' side='right' caption='E. coli DsbC complex with MES (PDB code [[1eej]])' scene=''> | <StructureSection load='1eej' size='340' side='right' caption='E. coli DsbC complex with MES (PDB code [[1eej]])' scene=''> | ||
== Function == | == Function == | ||
'''Thiol:disulfide interchange protein''' | '''Thiol:disulfide interchange protein''' is a prokaryotic disulfide bond isomerase. <br /> | ||
*'''DsbA''' see [[Protein disulfide oxidoreductase]]<br /> | |||
*'''DsbC''' acts as a proofreader and breaks the incorrectly formed disulfide bonds. DsbC is activated by the N terminal domain of DsbD<ref>PMID:9352906</ref>.<br /> | *'''DsbC''' acts as a proofreader and breaks the incorrectly formed disulfide bonds. DsbC is activated by the N terminal domain of DsbD<ref>PMID:9352906</ref>.<br /> | ||
*'''DsbD''' transfers electrons from the cytoplasmic thioredoxin to the periplasm thus maintaining the active site of DsbC, DsbE and DsbG in a reduced state<ref>PMID:10712691</ref>.<br /> | *'''DsbD''' transfers electrons from the cytoplasmic thioredoxin to the periplasm thus maintaining the active site of DsbC, DsbE and DsbG in a reduced state<ref>PMID:10712691</ref>.<br /> | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
* Thiol:disulfide interchange protein (DsbC) | * Thiol:disulfide interchange protein (DsbC) | ||