5k09: Difference between revisions

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-'''Unreleased structure'''
+{{Large structure}}
+==Crystal Structure of COMT in complex with a thiazole ligand==
-The entry 5k09 is ON HOLD
+<StructureSection load='5k09' size='340' side='right' caption='[[5k09]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
+== Structural highlights ==
-Authors: Ehler, A., RODRIGUEZ-SARMIENTO, R.M., Rudolph, M.G.
+<table><tr><td colspan='2'>[[5k09]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K09 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K09 FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6PQ:5-{3-[(4-METHOXYPHENYL)METHYL]-1H-PYRAZOL-5-YL}-2,4-DIMETHYL-1,3-THIAZOLE'>6PQ</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-Description: Crystal Structure of COMT in complex with a thiazole ligand
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k09 OCA], [http://pdbe.org/5k09 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k09 RCSB], [http://www.ebi.ac.uk/pdbsum/5k09 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k09 ProSAT]</span></td></tr>
+</table>
+{{Large structure}}
+== Function ==
+[[http://www.uniprot.org/uniprot/COMT_RAT COMT_RAT]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
+__TOC__
+</StructureSection>
+[[Category: Catechol O-methyltransferase]]
 [[Category: Ehler, A]]
-[[Category: Rodriguez-Sarmiento, R.M]]
+[[Category: RODRIGUEZ-SARMIENTO, R M]]
-[[Category: Rudolph, M.G]]
+[[Category: Rudolph, M G]]
+[[Category: Catechol]]
+[[Category: Methyltransferase]]
+[[Category: Neurotransmitter degradation]]
+[[Category: Transferase]]