5ja3: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5ja3 is ON HOLD  until Paper Publication
+==Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta- NADPH and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-b iphenyl]-4-carboxylic acid (UCP1106)==
+<StructureSection load='5ja3' size='340' side='right' caption='[[5ja3]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
-Authors: Hajian, B., Anderson, A.C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ja3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JA3 FirstGlance]. <br>
-Description: Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta-NADPH and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-b iphenyl]-4-carboxylic acid (UCP1106)
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=U06:4-[3-[3-[2,4-BIS(AZANYL)-6-ETHYL-PYRIMIDIN-5-YL]PROP-2-YNYL]-4-METHOXY-PHENYL]BENZOIC+ACID'>U06</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
-[[Category: Anderson, A.C]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ja3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ja3 OCA], [http://pdbe.org/5ja3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ja3 RCSB], [http://www.ebi.ac.uk/pdbsum/5ja3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ja3 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DYR_MYCTO DYR_MYCTO]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Dihydrofolate reductase]]
+[[Category: Anderson, A C]]
 [[Category: Hajian, B]]
+[[Category: Antifolate]]
+[[Category: Dhfr]]
+[[Category: Folate pathway]]
+[[Category: Oxidoreductase]]