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==Crystal structure of the kainate receptor GluK4 ligand binding domain in complex with kainate== | |||
<StructureSection load='5ikb' size='340' side='right' caption='[[5ikb]], [[Resolution|resolution]] 2.05Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ikb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IKB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IKB FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KAI:3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE'>KAI</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ikb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ikb OCA], [http://pdbe.org/5ikb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ikb RCSB], [http://www.ebi.ac.uk/pdbsum/5ikb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ikb ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/GRIK4_RAT GRIK4_RAT]] Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > glutamate >> AMPA. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Frydenvang, K]] | |||
[[Category: Kastrup, J S]] | |||
[[Category: Kristensen, L B]] | |||
[[Category: Kristensen, O]] | |||
[[Category: High-affinity kainate receptor]] | |||
[[Category: Ion channel]] | |||
[[Category: Ligand binding domain]] | |||
[[Category: Membrane protein]] | |||
Revision as of 09:51, 10 September 2016
Crystal structure of the kainate receptor GluK4 ligand binding domain in complex with kainateCrystal structure of the kainate receptor GluK4 ligand binding domain in complex with kainate
Structural highlights
Function[GRIK4_RAT] Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > glutamate >> AMPA. |
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